3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylic acid

Base Information

Chemical Name:3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylic acid
CAS No.:1445877-08-6
Molecular Formula:C₂₀H₂₁ClN₄O₃
Molecular Weight:400.865
Hs Code.:

Synonyms:3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylic acid

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Chemical Property of 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylic acid

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Technology Process of 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylic acid

There total 8 articles about 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1445877-24-6
methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate

: 1445877-08-6
3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylic acid

Guidance literature:: methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate; With lithium hydroxide; In tetrahydrofuran; at 60 ℃; for 5h;

With formic acid; In water; pH=1;

Reference yield:

: 907545-47-5
2-chloro-5-nitro-pyridine-4-carboxylic acid

: 1445877-08-6
3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / 4 h / 100 °C

2.1: copper diacetate; potassium tert-butylate; methylamine hydrochloride / N,N-dimethyl-formamide / 16 h / 60 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / tetrahydrofuran / 16 h / 20 °C

4.1: acetic acid; hydrogen; palladium 10% on activated carbon / methanol / 16 h / 20 °C

5.1: 16 h / Reflux

6.1: sodium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

7.1: lithium hydroxide / tetrahydrofuran / 5 h / 60 °C

7.2: pH 1

With palladium 10% on activated carbon; potassium tert-butylate; hydrogen; methylamine hydrochloride; copper diacetate; sodium carbonate; potassium carbonate; acetic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1445877-16-6
2-morpholino-5-nitroisonicotinic acid

: 1445877-08-6
3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper diacetate; potassium tert-butylate; methylamine hydrochloride / N,N-dimethyl-formamide / 16 h / 60 °C

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / tetrahydrofuran / 16 h / 20 °C

3.1: acetic acid; hydrogen; palladium 10% on activated carbon / methanol / 16 h / 20 °C

4.1: 16 h / Reflux

5.1: sodium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

6.1: lithium hydroxide / tetrahydrofuran / 5 h / 60 °C

6.2: pH 1

With palladium 10% on activated carbon; potassium tert-butylate; hydrogen; methylamine hydrochloride; copper diacetate; sodium carbonate; acetic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;