methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate

Base Information

Chemical Name:methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate
CAS No.:1445877-24-6
Molecular Formula:C₂₁H₂₃ClN₄O₃
Molecular Weight:414.892
Hs Code.:

Synonyms:methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate

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Chemical Property of methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate

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Technology Process of methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate

There total 7 articles about methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1445877-20-2
methyl 2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate

: 90369-76-9
1-(bromomethyl)-3-chloro-2-methyl benzene

: 1445877-24-6
methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

Reference yield:

: 907545-47-5
2-chloro-5-nitro-pyridine-4-carboxylic acid

: 1445877-24-6
methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / 4 h / 100 °C

2: copper diacetate; potassium tert-butylate; methylamine hydrochloride / N,N-dimethyl-formamide / 16 h / 60 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / tetrahydrofuran / 16 h / 20 °C

4: acetic acid; hydrogen; palladium 10% on activated carbon / methanol / 16 h / 20 °C

5: 16 h / Reflux

6: sodium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

With palladium 10% on activated carbon; potassium tert-butylate; hydrogen; methylamine hydrochloride; copper diacetate; sodium carbonate; potassium carbonate; acetic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1445877-18-8
methyl 2-amino-6-morpholino-5-nitroisonicotinic acid

: 1445877-24-6
methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; hydrogen; palladium 10% on activated carbon / methanol / 16 h / 20 °C

2: 16 h / Reflux

3: sodium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

With palladium 10% on activated carbon; hydrogen; sodium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide;