(αS)-4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetic acid

Base Information

Chemical Name:(αS)-4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetic acid
CAS No.:770741-51-0
Molecular Formula:C₂₇H₃₄Cl₂N₂O₃
Molecular Weight:505.485
Hs Code.:

Synonyms:(αS)-4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetic acid

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Chemical Property of (αS)-4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetic acid

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Technology Process of (αS)-4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetic acid

There total 3 articles about (αS)-4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 770741-13-4
(αS)-methyl 4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetate

: 770741-51-0
(αS)-4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetic acid

Guidance literature:: (αS)-methyl 4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetate; With tetra(n-butyl)ammonium hydroxide; In acetonitrile; at 20 ℃; for 3h;

With ammonium acetate; In tert-butyl methyl ether; water; acetonitrile; at 20 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: C₁₈H₂₃Cl₂NO₃

: 770741-51-0
(αS)-4-[[4-(3,4-dichloro-2-methylphenoxy)-1-piperidinyl]methyl]-α-(phenylmethyl)-1-piperidineacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium triacetoxy borohydride; acetic acid / 18 h / 20 °C

2: water; lithium hydroxide / methanol; tetrahydrofuran / 18 h / 20 °C

With sodium triacetoxy borohydride; water; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2012.08.103