3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine

Base Information

• Chemical Name: 3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine
• CAS No.: 173202-64-7
• Molecular Formula: C₅₀H₄₈N₂O₁₁S₂
• Molecular Weight: 917.07
• Mol file: 173202-64-7.mol

Synonyms:3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine

Chemical Property of 3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine

There total 3 articles about 3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

p-toluenesulfonyl chloride (98-59-9) + 3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine (157429-98-6) → 3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine (173202-64-7)

Guidance literature:

In pyridine; Ambient temperature;

DOI:10.1002/hlca.19950780714

Reference yield:

1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione (101527-47-3) → 3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine (173202-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / DBU / acetonitrile / 1 h / 60 °C

2: 84 percent / pyridine / Ambient temperature

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; acetonitrile;

DOI:10.1002/hlca.19950780714

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine (173202-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / DBU / acetonitrile / 1 h / 60 °C

2: 84 percent / pyridine / Ambient temperature

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; acetonitrile;

DOI:10.1002/hlca.19950780714

upstream raw materials:

p-toluenesulfonyl chloride

3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine

1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione

p-methoxybenzyl chloride

Downstream raw materials:

2'-Deoxy-3-(4-methoxybenxyl)-3'-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridin-1'-ene

3'-Azido-2',3'-dideoxy-5'-O-(triphenylmethyl)-2',3'-secouridin-1'-ene

3'-Azido-2',3'-dodeoxy-3-(4-methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-secouridin-1'-ene