(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

Base Information

Chemical Name:(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
CAS No.:923932-43-8
Molecular Formula:C₁₉H₂₀FNO₃
Molecular Weight:331.355
Hs Code.:

Synonyms:(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

Suppliers and Price of (3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of (3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

There total 10 articles about (3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005412-34-9
(3S,4R)-4-nitrophenyl 3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

: 923932-43-8
(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

Guidance literature:: With sodium hydroxide; water; In 1,4-dioxane; at 70 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 1131450-88-8
(3S,4R)-4-phenyl 3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

: 923932-43-8
(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

Guidance literature:: (3S,4R)-4-phenyl 3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate; With sodium hydroxide; In water; isopropyl alcohol; for 8.75h; Heating / reflux;

at 35 - 55 ℃; for 2h; Product distribution / selectivity;

Reference yield:

: 923932-05-2
benzo[d][1,3]dioxol-(2,2-d2)-5-ol

: 923932-43-8
(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetraoctyl ammonium bromide / water; toluene / 5 h / 90 °C

2.1: toluene / 8.5 h / 90 - 105 °C

2.2: 1 h / 60 °C

3.1: sodium hydroxide / water; isopropyl alcohol / 8.75 h / Heating / reflux

3.2: 2 h / 35 - 55 °C

With sodium hydroxide; tetraoctyl ammonium bromide; In water; isopropyl alcohol; toluene;