(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride

Base Information

Chemical Name:(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride
CAS No.:923932-15-4
Molecular Formula:C₁₉H₂₀FNO₃*ClH
Molecular Weight:367.816
Hs Code.:

Synonyms:(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride

Suppliers and Price of (3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride

There total 13 articles about (3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 936838-89-0
trans-(4R,3S)-d2-3-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)-piperidine-1-carboxylic acid 2-chloroethyl ester

: 923932-15-4
(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride

Guidance literature:: trans-(4R,3S)-d2-3-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)-piperidine-1-carboxylic acid 2-chloroethyl ester; With sodium hydroxide; water; isopropyl alcohol; for 12h; Heating / reflux;

With hydrogenchloride; In water; isopropyl alcohol; for 0.25h;

Reference yield:

: 923932-43-8
(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

: 923932-15-4
(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride

Guidance literature:: With hydrogenchloride; In hexanes; diethyl ether; acetone; at 0 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 105812-81-5
(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine

: 923932-15-4
(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 6 h / 20 °C

2.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 5 h / 90 °C

3.1: N-ethyl-N,N-diisopropylamine / toluene / 5 h / 80 °C

4.1: sodium hydroxide / water; 1,4-dioxane / 3 h / 70 °C

4.2: 1 h / 0 °C

With tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; toluene;
DOI:10.1124/jpet.115.223768