(3S,4R)-4-nitrophenyl 3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

Base Information

Chemical Name:(3S,4R)-4-nitrophenyl 3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate
CAS No.:1005412-34-9
Molecular Formula:C₂₆H₂₃FN₂O₇
Molecular Weight:496.46
Hs Code.:

Synonyms:(3S,4R)-4-nitrophenyl 3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

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Chemical Property of (3S,4R)-4-nitrophenyl 3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (3S,4R)-4-nitrophenyl 3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

There total 8 articles about (3S,4R)-4-nitrophenyl 3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 936838-88-9
(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine

: 7693-46-1
4-Nitrophenyl chloroformate

: 1005412-34-9
(3S,4R)-4-nitrophenyl 3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In toluene; at 80 ℃; for 5h;
DOI:10.1124/jpet.115.223768

Reference yield:

: 105812-81-5
(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine

: 1005412-34-9
(3S,4R)-4-nitrophenyl 3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 6 h / 20 °C

2: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 5 h / 90 °C

3: N-ethyl-N,N-diisopropylamine / toluene / 5 h / 80 °C

With tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water; toluene;
DOI:10.1124/jpet.115.223768

Reference yield:

: 923932-05-2
benzo[d][1,3]dioxol-(2,2-d2)-5-ol

: 1005412-34-9
(3S,4R)-4-nitrophenyl 3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 5 h / 90 °C

2: N-ethyl-N,N-diisopropylamine / toluene / 5 h / 80 °C

With tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; toluene;
DOI:10.1124/jpet.115.223768