25307-82-8

Basic information

• Product Name: METHYL 3-AMINO-2,2-DIMETHYLPROPANOATE
• Synonyms: METHYL 3-AMINO-2,2-DIMETHYLPROPANOATE;(2-Methoxycarbonyl-2-methylpropyl)amine;Propanoic acid,3-amino-2,2-dimethyl-,methyl ester
• CAS NO: 25307-82-8
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.17292
• Mol File: 25307-82-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 63-64℃ (14 Torr)
• Appearance: /
• Density: 0.973±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.76±0.10(Predicted)
• CAS DataBase Reference: METHYL 3-AMINO-2,2-DIMETHYLPROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-AMINO-2,2-DIMETHYLPROPANOATE(25307-82-8)
• EPA Substance Registry System: METHYL 3-AMINO-2,2-DIMETHYLPROPANOATE(25307-82-8)

Safety Data

• Hazardous Substances Data: 25307-82-8(Hazardous Substances Data)

Usage

General Description

Methyl 3-amino-2,2-dimethylpropanoate is a chemical compound with the molecular formula C6H13NO2. It is a derivative of amino acid proline and is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is a white solid at room temperature and is soluble in polar organic solvents. This chemical compound is known for its use as a chiral auxiliary in asymmetric synthesis and has applications in the production of chiral drugs and biologically active molecules.

Upstream product

• 288-32-4 1H-imidazole 
• 1079-66-9 chloro-diphenylphosphine 
• 7757-82-6 sodium sulfate 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 
• 41461-75-0 chloro-pivalic acid amide 
• 4300-97-4 3-Chloropivaloyl chloride 
• 4835-90-9 3-Hydroxy-2,2-dimethylpropanoic acid 
• 72291-30-6 methyl 2,2-dimethyl-cyanoacetate 
• 259794-51-9 methyl 2,2-dimethyl-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoate 
• 114583-17-4 α-(nitromethyl)isobutyronitrile 
• 324763-51-1 aminopivalinamide 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 94143-84-7 2,2-dimethyl-N,N-bis(trimethylsilyl)-β-alanine methyl ester 
• 186581-53-3 diazomethane 

Downstream Products

• 362703-25-1 C₂₄H₂₆N₂O₄ 
• 324763-51-1 aminopivalinamide 
• 1455089-62-9 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid 
• 1455094-05-9 methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate 
• 1455089-57-2 3-[(1-cyano-4-hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid 
• 1455093-94-3 3-[(1-cyano-4-hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid methyl ester 
• 1455093-92-1 3-[(1-cyano-4-hydroxy-7-phenethylisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid methyl ester 
• 1455093-84-1 3-[(1-cyano-4-hydroxy-7-(phenylsulfanyl)isoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid methyl ester 
• 1419610-39-1 methyl 3-[({3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]-2,2-dimethylpropanoate 
• 1392839-19-8 3-[(1-benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid methyl ester 
• 1392839-58-5 3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester 

Relevant articles and documents

AROMATIC COMPOUND

Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.

Method for the Production of Aminoalkane Acid Amides

The invention relates to a process for preparing aminoalkanamides by reacting cyanoalkanoic esters with a) ammonia or an amine and b) hydrogen in the presence of a catalyst, the reaction with component b) being started simultaneously or not later than a maximum of 100 minutes after commencement of the reaction of the cyanoalkanoic ester with component a).

SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.