25307-82-8

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3-AMINO-2,2-DIMETHYLPROPANOATE is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its role in the creation of chiral drugs is particularly significant, as it aids in the production of molecules with specific spatial arrangements that are crucial for their biological activity and efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 3-AMINO-2,2-DIMETHYLPROPANOATE is utilized as a precursor in the synthesis of agrochemicals, including pesticides and herbicides. Its involvement in the production of these compounds helps to enhance crop protection and contribute to increased agricultural productivity.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
METHYL 3-AMINO-2,2-DIMETHYLPROPANOATE is employed as a chiral auxiliary in asymmetric synthesis, a technique that allows for the selective production of enantiomers, which are molecules that are mirror images of each other. This selective synthesis is vital for creating biologically active molecules with specific desired properties, as the spatial arrangement of atoms can significantly impact the molecule's interaction with biological targets.

Upstream product

• 67-56-1 methanol 
• 19036-43-2 aminopivalic acid 
• 186581-53-3 diazomethane 
• 94143-84-7 2,2-dimethyl-N,N-bis(trimethylsilyl)-β-alanine methyl ester 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 324763-51-1 aminopivalinamide 
• 114583-17-4 α-(nitromethyl)isobutyronitrile 
• 288-32-4 1H-imidazole 
• 1079-66-9 chloro-diphenylphosphine 
• 7757-82-6 sodium sulfate 
• 72291-30-6 methyl 2,2-dimethyl-cyanoacetate 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 
• 41461-75-0 chloro-pivalic acid amide 
• 4300-97-4 3-Chloropivaloyl chloride 

Downstream Products

• 362703-25-1 C₂₄H₂₆N₂O₄ 
• 324763-51-1 aminopivalinamide 
• 1392839-58-5 3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester 
• 1392839-19-8 3-[(1-benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid methyl ester 
• 1419610-39-1 methyl 3-[({3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]-2,2-dimethylpropanoate 
• 1455093-84-1 3-[(1-cyano-4-hydroxy-7-(phenylsulfanyl)isoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid methyl ester 
• 1455093-92-1 3-[(1-cyano-4-hydroxy-7-phenethylisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid methyl ester 
• 1455093-94-3 3-[(1-cyano-4-hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid methyl ester 
• 1455089-57-2 3-[(1-cyano-4-hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid 
• 1455094-05-9 methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate 
• 1455089-62-9 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid 

Relevant academic research and scientific papers

AROMATIC COMPOUND

Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.

METHOD FOR THE PREPARATION OF OMEGA-AMINO-ALKANEAMIDES AND OMEGA-AMINO-ALKANETHIOAMIDES AS WELL AS INTERMEDIATES OF THIS METHOD

The present invention relates to method for the preparation of an ω-amino-alkane(thio)amide having the formula (3). Furthermore, novel intermediates and partial reaction steps of the claimed method are disclosed.

Method for the Production of Aminoalkane Acid Amides

The invention relates to a process for preparing aminoalkanamides by reacting cyanoalkanoic esters with a) ammonia or an amine and b) hydrogen in the presence of a catalyst, the reaction with component b) being started simultaneously or not later than a maximum of 100 minutes after commencement of the reaction of the cyanoalkanoic ester with component a).

SUBSTITUTED PYRIMIDODIAZEPINES

The present invention provides PLK1 inhibitor compounds of formula I: Useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the t

SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.

Hypocholesterolemic agents

This invention relates to certain steroidal glycosides useful as hypocholesterolemic agents and antiatherosclerosis agents and certain protected intermediates useful in the preparation of said steroidal glycosides.

Fibrinogen receptor antagonists

Fibrinogen receptor antagonists of the STR1 are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets wherein G is: STR2 for example, STR3

Fibrinogen receptor antagonists

Fibrinogen receptor antagonists of the formula: STR1 are disclosed for use in inhibiting the aggregation of blood platelets. wherein G is: STR2

Fibrinogen receptor antagonists

Fibrinogen receptor antagonists of the formula: STR1 are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets wherein G is: STR2

Primary Aminomethylation at the α-Position of Carboxylic Acids and Esters. Trimethylsilyl Triflate-Catalyzed Reaction of Ketene Silyl Acetals with N,N-Bis(trimethylsilyl)methoxymethylamine

A new, general method for the synthesis of β-aminocarboxylic esters (9) and acids (10) was developed.The introduction of primary aminomethyl unit at the α-position of carboxylic esters (2) and acids (3) was achieved in high yields by the silyl trifluorome