(S)-2-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-benzylamino]-3-phenyl-propionic acid cyclopentyl ester

Base Information

• Chemical Name: (S)-2-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-benzylamino]-3-phenyl-propionic acid cyclopentyl ester
• CAS No.: 914606-10-3
• Molecular Formula: C₃₈H₄₇N₃O₅S
• Molecular Weight: 657.874
• Mol file: 914606-10-3.mol

Synonyms:(S)-2-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-benzylamino]-3-phenyl-propionic acid cyclopentyl ester

Chemical Property of (S)-2-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-benzylamino]-3-phenyl-propionic acid cyclopentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-benzylamino]-3-phenyl-propionic acid cyclopentyl ester

There total 14 articles about (S)-2-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-benzylamino]-3-phenyl-propionic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

(S)-2-(4-aminomethyl-benzylamino)-3-phenyl-propionic acid cyclopentyl ester (914606-09-0) + 6-formyl-benzo[b]thiophene-2-carboxylic acid (1-isobutoxy-ethoxy) amide (914452-25-8) → (S)-2-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-benzylamino]-3-phenyl-propionic acid cyclopentyl ester (914606-10-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,1-dichloroethane; at 20 ℃; for 3h;

Reference yield:

4-hydroxymethyl-benzylamine (39895-56-2) → (S)-2-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-benzylamino]-3-phenyl-propionic acid cyclopentyl ester (914606-10-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 °C / pH > 9

2.1: lithium aluminium tetrahydride / tetrahydrofuran; 1,4-dioxane / 16.25 h / 0 - 20 °C

3.1: Dess-Martin periodane / dichloromethane / 3 h / -78 - 20 °C

4.1: 1,1-dichloroethane / 0.25 h / 20 °C

4.2: 1 h

5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

6.1: sodium tris(acetoxy)borohydride; acetic acid / 1,1-dichloroethane / 3 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; In tetrahydrofuran; 1,4-dioxane; 1,1-dichloroethane; dichloromethane; water;

Reference yield:

benzo[b]thiophene-2,6-dicarboxylic acid 2-ethyl ester (850074-43-0) → (S)-2-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-benzylamino]-3-phenyl-propionic acid cyclopentyl ester (914606-10-3)

Guidance literature:

Multi-step reaction with 5 steps

1: boron trifluoride / tetrahydrofuran / 3 h / 0 - 20 °C

2: lithium hydroxide; water / tetrahydrofuran / 3 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 2 h / 20 °C

4: manganese(IV) oxide / dichloromethane / 0.5 h / 20 °C

5: sodium tris(acetoxy)borohydride; acetic acid / 1,1-dichloroethane / 3 h / 20 °C

With manganese(IV) oxide; lithium hydroxide; boron trifluoride; water; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; 1,1-dichloroethane; dichloromethane;

upstream raw materials:

(S)-2-(4-aminomethyl-benzylamino)-3-phenyl-propionic acid cyclopentyl ester

6-formyl-benzo[b]thiophene-2-carboxylic acid (1-isobutoxy-ethoxy) amide

2-ethyl 6-methyl benzo[b]thiophene-2,6-dicarboxylate

benzo[b]thiophene-2,6-dicarboxylic acid 2-ethyl ester