850074-43-0

Basic information

• Product Name: 2-ethoxycarbonylbenzothiophene-6-carboxylic acid
• Synonyms: 2-(ethoxycarbonyl)-1-benzothiophene-6-carboxylic acid
• CAS NO: 850074-43-0
• Molecular Formula: C₁₂H₁₀O₄S
• Molecular Weight: 250.27
• Mol File: 850074-43-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 443.3°C at 760 mmHg
• Flash Point: 221.9°C
• Density: 1.39g/cm³
• Vapor Pressure: 1.22E-08mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: 2-ethoxycarbonylbenzothiophene-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethoxycarbonylbenzothiophene-6-carboxylic acid(850074-43-0)
• EPA Substance Registry System: 2-ethoxycarbonylbenzothiophene-6-carboxylic acid(850074-43-0)

Safety Data

• Hazardous Substances Data: 850074-43-0(Hazardous Substances Data)

Upstream product

• 850074-42-9 2-ethyl 6-methyl benzo[b]thiophene-2,6-dicarboxylate 
• 104447-80-5 (E)-1-(dimethylamino)-2-[4-(methoxycarbonyl)-2-nitrophenyl]ethene 
• 7356-11-8 4-methyl-3-nitro-benzoic acid methyl ester 
• 153813-69-5 methyl 4-formyl-3-nitrobenzoate 

Downstream Products

• 850072-65-0 6-hydroxymethyl-benzo[b]thiophene-2-carboxylic acid ethyl ester 
• 914452-64-5 (S)-tert-butoxycarbonylamino-{4-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-phenoxy]-phenyl}-acetic acid cyclopentyl ester 
• 914645-85-5 2-(S)-tert-butoxycarbonylamino-3-{4-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-phenoxy]-cyclohexyl}-propionic acid cyclopentyl ester 
• 102636-02-2 6-hydroxymethyl-benzo[b]thiophene-2-carboxylic acid 
• 914606-40-9 (S)-[tert-butoxycarbonyl-(3-{[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]-thiophen-6-ylmethyl]-amino}-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester 
• 914606-10-3 (S)-2-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-benzylamino]-3-phenyl-propionic acid cyclopentyl ester 
• 914645-16-2 (S)-{[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid tert-butyl ester 
• 913739-27-2 C₂₅H₂₉N₃O₃S 
• 850074-68-9 6-[(4-methoxy-benzylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid ethyl ester 

Relevant articles and documents

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Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers: formula (I) wherein Y1 is a bond, -(C=O)-, -S(O2)-, -C(=O)O-, -OC(=O)-, -(C=O)NR3, -NR3(C=O)-, -S(O2)NR3-, -NR3S(O2)-, or -NR3(C=O)NR5-, wherein R3 and R5 are independently hydrogen or optionally substituted (C1-C6)alkyl, L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, AIk1, AIk2 and Q are as defined in the claims; z is O or 1 ; A represents an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; -[Linker]- represents a divalent linker radical; R is a radical of formula (X) or (Y); wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroary(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and B is a monocyclic heterocyclic ring of 5 or 6 ring atoms wherein R1 is linked to a ring carbon adjacent the ring nitrogen shown, and ring B is optionally fused to a second carbocyclic or heterocyclic ring of 5 or 6 ring atoms in which case the bond shown intersected by a wavy line may be from a ring atom in said second ring.