1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE

Base Information

• Chemical Name: 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE
• CAS No.: 214701-49-2
• Molecular Formula: C7H6BrNO
• Molecular Weight: 200.035
• Hs Code.: 2933399090
• Mol file: 214701-49-2.mol

Synonyms:1-(5-Bromopyridin-2-yl)ethanone;

Chemical Property of 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE

Chemical Property:

• Melting Point: 112 °C
• Boiling Point: 257.2 °C at 760 mmHg
• PKA: 0?+-.0.10(Predicted)
• Flash Point: 109.4 °C
• PSA: 29.96000
• Density: 1.534 g/cm³
• LogP: 2.04670
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Sparingly), Methanol (Sparingly)

Purity/Quality:

99% ^*data from raw suppliers

1-(5-Bromo-2-pyridyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(5-Bromo-2-pyridyl)ethanone is a reagent used to synthesize substituted pyridin-3-yl)phenyloxazolidinones as antibacterial agents with reduced activity against monoamine oxidase A.

Technology Process of 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE

There total 11 articles about 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,5-dibromopyridine (624-28-2) + N,N-dimethyl acetamide (127-19-5,116057-81-9) → 1-(5-bromopyridin-2-yl)ethanone (214701-49-2)

Guidance literature:

With n-butyllithium; In hexane; toluene; at -40 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 91.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + 2-iodo-5-bromopyridine (223463-13-6) → 1-(5-bromopyridin-2-yl)ethanone (214701-49-2)

Guidance literature:

2-iodo-5-bromopyridine; With n-butyllithium; In hexane; toluene; at -40 ℃; for 1h;

N,N-dimethyl acetamide; In hexane; toluene; at -40 - 20 ℃; for 1h;

DOI:10.1002/anie.202008439

Reference yield: 90.0%

5-bromo-N-methyoxy-N-methylpyridine-2-carboxamide (1211592-38-9) + methylmagnesium chloride (676-58-4) → 1-(5-bromopyridin-2-yl)ethanone (214701-49-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 1h;

upstream raw materials:

methylmagnesium bromide

2-Cyano-5-bromopyridine

3-bromo-6-(trimethylsilylethynyl)pyridine

2,5-dibromopyridine

Downstream raw materials:

1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboralan-2-yl)pyridin-2-yl)ethan-1-one

1-[5-[2-(4-fluorophenyl)ethynyl]-2-pyridyl]-2-imidazol-1-yl-N-methoxyethanimine

6-bromo-3-methyl-[1,2,3]triazolo[1,5-a]pyridine

2-(5-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)-2-pyridinyl)-1,1,1-trifluoro-2-propanol