N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

Base Information

Chemical Name:N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide
CAS No.:1243147-88-7
Molecular Formula:C₁₉H₂₂N₂O₃S
Molecular Weight:358.461
Hs Code.:

Synonyms:N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

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Chemical Property of N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

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Technology Process of N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

There total 1 articles about N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 51765-60-7
N-(4-amino-2-phenoxy phenyl) methanesulfonamide

: 67-64-1
acetone

: 1243147-88-7
N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

Guidance literature:: With ammonium cerium (IV) nitrate; at 55 ℃; for 24h;
DOI:10.2174/157017810791130586

Reference yield: 73.0%

: 1243147-88-7
N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

: 106-96-7
propargyl bromide

: 1343480-60-3
N-(2,2,4-trimethyl-7-phenoxy-1-(prop-2-ynyl)-1,2-dihydroquinolin-6-yl)methanesulphonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.08.033

Reference yield:

: 1243147-88-7
N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

: 1343480-69-2
N-(2,2,4-trimethyl-1-(3-(2-chlorophenyl)prop-2-ynyl)-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2: copper(l) iodide; palladium diacetate; triethylamine / tetrahydrofuran / 20 h / 50 - 55 °C / Inert atmosphere

With copper(l) iodide; palladium diacetate; potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1016/j.bmcl.2011.08.033