(2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid

Base Information

Chemical Name:(2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid
CAS No.:187872-77-1
Molecular Formula:C₃₇H₃₆N₂O₆
Molecular Weight:604.703
Hs Code.:

Synonyms:(2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid

Suppliers and Price of (2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid

There total 10 articles about (2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 187872-75-9
(2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid tert-butyl ester

: 187872-77-1
(2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm960553d

Reference yield:

: 4385-35-7
isochroman-3-one

: 187872-77-1
(2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NH₄NO₃, trifluoroacetic anhydride, 2.) LDA

2: 48 percent / H₂SO₄ / Heating

3: 58 percent / CBr₄, Ph₃P / tetrahydrofuran / 3 h / Ambient temperature

4: 91 percent / Et₃N / tetrahydrofuran / 2 h / 45 °C

5: 47 percent / AcOH / toluene / Heating

6: 83 percent / ammonium formate, HCO₂H / 10percent Pd/C / CH₂Cl₂ / 1 h / Ambient temperature

7: 88 percent / pyridine / Ambient temperature

8: 84 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; ammonium nitrate; formic acid; carbon tetrabromide; sulfuric acid; ammonium formate; acetic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; trifluoroacetic anhydride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm960553d

Reference yield:

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 187872-77-1
(2S,3S)-2-[(R)-7-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-benzyl)-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NH₄NO₃, trifluoroacetic anhydride, 2.) LDA

2: 48 percent / H₂SO₄ / Heating

3: 58 percent / CBr₄, Ph₃P / tetrahydrofuran / 3 h / Ambient temperature

4: 91 percent / Et₃N / tetrahydrofuran / 2 h / 45 °C

5: 47 percent / AcOH / toluene / Heating

6: 83 percent / ammonium formate, HCO₂H / 10percent Pd/C / CH₂Cl₂ / 1 h / Ambient temperature

7: 88 percent / pyridine / Ambient temperature

8: 84 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; ammonium nitrate; formic acid; carbon tetrabromide; sulfuric acid; ammonium formate; acetic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; trifluoroacetic anhydride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm960553d