3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoic acid

Base Information

Chemical Name:3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoic acid
CAS No.:1445787-56-3
Molecular Formula:C₂₆H₂₄FN₅O₆
Molecular Weight:521.505
Hs Code.:

Synonyms:3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Chemical Property of 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Technology Process of 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoic acid

There total 11 articles about 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1445787-56-3
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1 h / 100 °C

2.1: diphenylether / 16 h / 240 °C

3.1: potassium hydroxide; water / tetrahydrofuran; methanol / 20 h / 45 °C

4.1: trichlorophosphate / 3 h / 110 °C

4.2: Cooling with ice

5.1: acetic acid / 16 h / 20 °C

6.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave irradiation

7.1: potassium hydroxide / tetrahydrofuran; methanol / 16 h / 35 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; caesium carbonate; acetic acid; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diphenylether; water;

Reference yield:

: 1445791-04-7
isopropyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate

: 1445787-56-3
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; at 35 ℃; for 16h;

Reference yield:

: 1445790-67-9
diethyl 2-(((3-bromo-2-fluorophenyl)amino)methylene)malonate

: 1445787-56-3
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: diphenylether / 16 h / 240 °C

2.1: potassium hydroxide; water / tetrahydrofuran; methanol / 20 h / 45 °C

3.1: trichlorophosphate / 3 h / 110 °C

3.2: Cooling with ice

4.1: acetic acid / 16 h / 20 °C

5.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave irradiation

6.1: potassium hydroxide / tetrahydrofuran; methanol / 16 h / 35 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; caesium carbonate; acetic acid; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diphenylether; water;