isopropyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate

Base Information

Chemical Name:isopropyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate
CAS No.:1445791-04-7
Molecular Formula:C₂₉H₃₀FN₅O₆
Molecular Weight:563.586
Hs Code.:

Synonyms:isopropyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate

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Chemical Property of isopropyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate

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Technology Process of isopropyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate

There total 10 articles about isopropyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1445791-04-7
isopropyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1 h / 100 °C

2.1: diphenylether / 16 h / 240 °C

3.1: potassium hydroxide; water / tetrahydrofuran; methanol / 20 h / 45 °C

4.1: trichlorophosphate / 3 h / 110 °C

4.2: Cooling with ice

5.1: acetic acid / 16 h / 20 °C

6.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; caesium carbonate; acetic acid; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diphenylether; water;

Reference yield:

: 1445791-02-5
isopropyl 3-((7-bromo-3-carbamoyl-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445791-04-7
isopropyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 110 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1445790-67-9
diethyl 2-(((3-bromo-2-fluorophenyl)amino)methylene)malonate

: 1445791-04-7
isopropyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-isopropoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diphenylether / 16 h / 240 °C

2.1: potassium hydroxide; water / tetrahydrofuran; methanol / 20 h / 45 °C

3.1: trichlorophosphate / 3 h / 110 °C

3.2: Cooling with ice

4.1: acetic acid / 16 h / 20 °C

5.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; caesium carbonate; acetic acid; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diphenylether; water;