(3S,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)hex-5-en

Base Information

• Chemical Name: (3S,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)hex-5-en
• CAS No.: 214959-70-3
• Molecular Formula: C₃₄H₄₂F₃NO₃Si
• Molecular Weight: 597.793

Synonyms:(3S,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)hex-5-en

Chemical Property of (3S,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)hex-5-en

Chemical Property:

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Technology Process of (3S,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)hex-5-en

There total 1 articles about (3S,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)hex-5-en which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-Butyldiphenylsilyl β-hydroxybutanone (97250-25-4) + trimethylsilyl ether of (1S,2S)-N-trifluoroacetamidonorpseudoephedrine (183378-05-4) + allyl-trimethyl-silane (762-72-1) → (3S,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)hex-5-en (214959-70-3)

Guidance literature:

With trifluorormethanesulfonic acid; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 5h;

DOI:10.1002/(SICI)1521-3765(19980904)4:9<1862::AID-CHEM1862>3.0.CO;2-C

Reference yield: 95.0%

(3S,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)hex-5-en (214959-70-3) → (3R,1'S,2'S)-5-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-1-pentanal (247256-57-1)

Guidance literature:

(3S,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)hex-5-en; With ozone; In methanol; dichloromethane; at -78 ℃;

With triphenylphosphine; at -78 ℃; for 0.5h;

DOI:10.1002/(SICI)1521-3765(19991001)5:10<2885::AID-CHEM2885>3.0.CO;2-8

Reference yield: 73.0%

(3S,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)hex-5-en (214959-70-3) → 2,2,2-Trifluoro-N-{(1S,2S)-2-[(S)-1-(2-hydroxy-ethyl)-1-methyl-but-3-enyloxy]-1-methyl-2-phenyl-ethyl}-acetamide (247256-66-2)

Guidance literature:

With hydrogen fluoride; In acetonitrile; at 20 ℃;

DOI:10.1002/1521-3773(20010302)40:5<901::AID-ANIE901>3.0.CO;2-F

upstream raw materials:

tert-Butyldiphenylsilyl β-hydroxybutanone

trimethylsilyl ether of (1S,2S)-N-trifluoroacetamidonorpseudoephedrine

allyl-trimethyl-silane

Downstream raw materials:

(3R,1'S,2'S)-5-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-1-pentanal

2,2,2-Trifluoro-N-{(1S,2S)-2-[(S)-1-(2-hydroxy-ethyl)-1-methyl-but-3-enyloxy]-1-methyl-2-phenyl-ethyl}-acetamide

1-[(S)-1-(2-Iodo-ethyl)-1-methyl-but-3-enyloxymethyl]-4-methoxy-benzene

1-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hex-5-en-3-ol

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