(S)-((R)-5,6-bis(nitrooxy)hexyl) 2-(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxamido)-3-phenylpropanoate

Base Information

Chemical Name:(S)-((R)-5,6-bis(nitrooxy)hexyl) 2-(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxamido)-3-phenylpropanoate
CAS No.:1185768-56-2
Molecular Formula:C₃₇H₄₀ClN₉O₉
Molecular Weight:790.232
Hs Code.:

Synonyms:(S)-((R)-5,6-bis(nitrooxy)hexyl) 2-(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxamido)-3-phenylpropanoate

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Chemical Property of (S)-((R)-5,6-bis(nitrooxy)hexyl) 2-(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxamido)-3-phenylpropanoate

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Technology Process of (S)-((R)-5,6-bis(nitrooxy)hexyl) 2-(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxamido)-3-phenylpropanoate

There total 4 articles about (S)-((R)-5,6-bis(nitrooxy)hexyl) 2-(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxamido)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R)-6-hydroxyhexane-1,2-diyl dinitrate

: 1185769-66-7
(2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid

: 1185768-56-2
(S)-((R)-5,6-bis(nitrooxy)hexyl) 2-(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxamido)-3-phenylpropanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 72h;

Reference yield:

: 124750-99-8
cozaar

: 1185768-56-2
(S)-((R)-5,6-bis(nitrooxy)hexyl) 2-(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxamido)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium periodate; rhodium(III) chloride hydrate; potassium hydroxide / water / 0 °C

1.2: 20 - 30 °C

2.1: triethylamine / dichloromethane / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

4.1: water; lithium hydroxide / methanol / 2 h / 20 °C

4.2: pH 3

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h

With dmap; sodium periodate; rhodium(III) chloride hydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; lithium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 960231-60-1
2-butyl-4-chloro-1-{[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid

: 1185768-56-2
(S)-((R)-5,6-bis(nitrooxy)hexyl) 2-(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxamido)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

2.1: water; lithium hydroxide / methanol / 2 h / 20 °C

2.2: pH 3

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h

With dmap; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;