(2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid

Base Information

Chemical Name:(2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid
CAS No.:1185769-66-7
Molecular Formula:C₃₁H₃₀ClN₇O₃
Molecular Weight:584.077
Hs Code.:

Synonyms:(2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid

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Chemical Property of (2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid

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Technology Process of (2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid

There total 4 articles about (2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185769-65-6
methyl (2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoate

: 1185769-66-7
(2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid

Guidance literature:: methyl (2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoate; With water; lithium hydroxide; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; water; pH=3;

Reference yield:

: 124750-99-8
cozaar

: 1185769-66-7
(2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium periodate; rhodium(III) chloride hydrate; potassium hydroxide / water / 0 °C

1.2: 20 - 30 °C

2.1: triethylamine / dichloromethane / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

4.1: water; lithium hydroxide / methanol / 2 h / 20 °C

4.2: pH 3

With sodium periodate; rhodium(III) chloride hydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; lithium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 960231-60-1
2-butyl-4-chloro-1-{[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid

: 1185769-66-7
(2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

2.1: water; lithium hydroxide / methanol / 2 h / 20 °C

2.2: pH 3

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In methanol; N,N-dimethyl-formamide;