N-Trityl Losartan Carboxylic Acid

Base Information

Chemical Name:N-Trityl Losartan Carboxylic Acid
CAS No.:960231-60-1
Molecular Formula:C₄₁H₃₅ClN₆O₂
Molecular Weight:679.221
Hs Code.:
Mol file:960231-60-1.mol

Synonyms:2-butyl-4-chloro-1-{[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid

Suppliers and Price of N-Trityl Losartan Carboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-TritylLosartanCarboxylicAcid
25mg
$ 1100.00

Total 3 raw suppliers

Chemical Property of N-Trityl Losartan Carboxylic Acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-TritylLosartanCarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses A Losartan derivative for treatment of hypertension.

Technology Process of N-Trityl Losartan Carboxylic Acid

There total 2 articles about N-Trityl Losartan Carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-83-5
trityl chloride

: 124750-92-1
2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

: 960231-60-1
2-butyl-4-chloro-1-{[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 124750-99-8
cozaar

: 960231-60-1
2-butyl-4-chloro-1-{[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium periodate; rhodium(III) chloride hydrate; potassium hydroxide / water / 0 °C

1.2: 20 - 30 °C

2.1: triethylamine / dichloromethane / 20 °C

With sodium periodate; rhodium(III) chloride hydrate; triethylamine; potassium hydroxide; In dichloromethane; water;

Reference yield: 70.0%

: 960231-60-1
2-butyl-4-chloro-1-{[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid

: 1207855-46-6
(S)-5-(5-(hydroxymethyl)-2-oxo-1,3-dioxol-4-yl)pentan-2-yl nitrate

: 1207855-67-1
(S)-(5-(4-(nitrooxy)pentyl)-2-oxo-1,3-dioxol-4-yl)methyl 2-butyl-4-chloro-1-((2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; at 0 ℃;

upstream raw materials:

trityl chloride

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

cozaar

Downstream raw materials:

methyl (2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoate

(S)-(5-(4-(nitrooxy)pentyl)-2-oxo-1,3-dioxol-4-yl)methyl 2-butyl-4-chloro-1-((2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate

{5-[(nitrooxy)methyl]-2-oxo-1,3-dioxol-4-yl}methyl2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate

(2S)-2-{[(2-butyl-4-chloro-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]amino}-3-phenylpropanoic acid

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