1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate
CAS No.:1150100-35-8
Molecular Formula:C₂₅H₂₈F₃N₃O₅
Molecular Weight:507.51
Hs Code.:

Synonyms:1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate

There total 2 articles about 1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 679409-18-8
tert-butyl 4-((3-fluorophenyl)amino)piperidine-1-carboxylate

: C₉H₆ClF₂NO₃

: 1150100-35-8
1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate

Guidance literature:: tert-butyl 4-((3-fluorophenyl)amino)piperidine-1-carboxylate; C₉H₆ClF₂NO₃; In dichloromethane; at 20 ℃; for 18h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 679409-18-8
tert-butyl 4-((3-fluorophenyl)amino)piperidine-1-carboxylate

: C₉H₅F₂NO₃

: 1150100-35-8
1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate

Guidance literature:: In dichloromethane; at 40 ℃; for 18h;

Reference yield: 86.0%

: 1150100-35-8
1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate

: 1150100-36-9
5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid

Guidance literature:: 1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 72h;

With hydrogenchloride; In water; pH=3;