2',3'-O,N⁴-tribenzoyl-5'-O-tert-butyldiphenylsilyl cytidine

Base Information

• Chemical Name: 2',3'-O,N⁴-tribenzoyl-5'-O-tert-butyldiphenylsilyl cytidine
• CAS No.: 302346-90-3
• Molecular Formula: C₄₆H₄₃N₃O₈Si
• Molecular Weight: 793.948

Synonyms:2',3'-O,N⁴-tribenzoyl-5'-O-tert-butyldiphenylsilyl cytidine

Chemical Property of 2',3'-O,N⁴-tribenzoyl-5'-O-tert-butyldiphenylsilyl cytidine

Chemical Property:

Purity/Quality:

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Technology Process of 2',3'-O,N⁴-tribenzoyl-5'-O-tert-butyldiphenylsilyl cytidine

There total 3 articles about 2',3'-O,N⁴-tribenzoyl-5'-O-tert-butyldiphenylsilyl cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoic acid anhydride (93-97-0) + 5'-O-(tert-butyldiphenylsilyl)cytidine (58479-65-5) → 2',3'-O,N4-tribenzoyl-5'-O-tert-butyldiphenylsilyl cytidine (302346-90-3)

Guidance literature:

In pyridine; at 20 ℃; for 48h;

DOI:10.1021/jo000646+

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 2',3'-O,N4-tribenzoyl-5'-O-tert-butyldiphenylsilyl cytidine (302346-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 1 h / 20 °C

2: pyridine / 48 h / 20 °C

With 1H-imidazole; In pyridine; N,N-dimethyl-formamide; 1: silylation / 2: Acylation;

DOI:10.1021/jo000646+

Reference yield:

CYTIDINE (65-46-3) → 2',3'-O,N4-tribenzoyl-5'-O-tert-butyldiphenylsilyl cytidine (302346-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 1 h / 20 °C

2: pyridine / 48 h / 20 °C

With 1H-imidazole; In pyridine; N,N-dimethyl-formamide; 1: silylation / 2: Acylation;

DOI:10.1021/jo000646+

upstream raw materials:

benzoic acid anhydride

5'-O-(tert-butyldiphenylsilyl)cytidine

tert-butylchlorodiphenylsilane

CYTIDINE

Downstream raw materials:

3-propenyl (2',3'-O,N⁴-tribenzoyl cytidine-5')-yl (methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-β-D-glycero-D-galacto-2-nonulopyranosid-2))-yl phosphorothioate

3-propenyl-(2',3'-O,N⁴-tribenzoyl cytidine-5')-yl-N,N'-diisopropylphosphoramidite

N,2',3'-O-tribenzoylcytidine

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