58479-65-5Relevant academic research and scientific papers
Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides
Panayides, Jenny-Lee,Mathieu, Véronique,Banuls, Laetitia Moreno Y.,Apostolellis, Helen,Dahan-Farkas, Nurit,Davids, Hajierah,Harmse, Leonie,Rey, M.E. Christine,Green, Ivan R.,Pelly, Stephen C.,Kiss, Robert,Kornienko, Alexander,Van Otterlo, Willem A.L.
, p. 2716 - 2724 (2016)
Seventeen silyl- and trityl-modified (5′-O- and 3′,5′-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a fixed concentra
Improved protocol for the synthesis of flexibly protected morpholino monomers from unprotected ribonucleosides
Pattanayak, Sankha,Paul, Sibasish,Nandi, Bappaditya,Sinha, Surajit
, p. 763 - 782 (2013/01/16)
An inexpensive and much improved protocol has been developed for the synthesis of protected morpholino monomers from unprotected ribonucleosides in high overall yield, using oxidative glycol cleavage and reductive amination strategy. Unlike the previous methods, the present strategy allows installing the exocyclic amine protections at a later stage, and thus avoids the use of expensive, or commercially unavailable, exocyclic amine-protected ribonucleosides as starting materials. To demonstrate the flexibility of the present method in choosing protecting groups, the monomers have been protected with several such groups of different deblocking properties at the exocyclic amine position.
Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase
Patrone, James D.,Yao, Jiangwei,Scott, Nicole E.,Dotson, Garry D.
supporting information; experimental part, p. 16340 - 16341 (2010/01/30)
(Figure Presented) Bacterial phosphopantothenolycysteine synthetase (PPCS) catalyzes the formation of phosphopantothenoylcysteine (PPC) from (R)-phosphopantothenate, L-cysteine, and cytidine-5′-triphosphate (CTP) and has been shown to be essential for gro
Synthesis and Characterization of an Anomeric Sulfur Analogue of CMP-Sialic Acid
Cohen, Scott B.,Halcomb, Randall L.
, p. 6145 - 6152 (2007/10/03)
α-2,3-Sialyltransferase catalyzes the transfer of sialic acid from CMP-sialic acid (1) to a lactose acceptor. An analogue of 1 was synthesized in which the anomeric oxygen atom was replaced with a sulfur atom (1S). The key step in the synthesis of IS was a tetrazole-promoted coupling of a cytidine-5′-phosphoramidite with a glycosyl thiol of a protected sialic acid. Compounds 1 and 1S were characterized for their activity in a sialyl transfer assay. The rate of solvolysis in aqueous buffer of analogue 1S was 50-fold slower than that of 1. Analogue 1S was found to be substrate for α-2,3-sialyltransferase. The Km of 1S was just 3-fold higher than that of 1, while the kcat of 1S was 2 orders of magnitude lower compared to 1.
Synthesis of CMP-sialic acid conjugates: Substrates for the enzymatic synthesis of natural and designed sialyl oligosaccharides
Chappell, Mark D.,Halcomb, Randall L.
, p. 11109 - 11120 (2007/10/03)
The syntheses of several congeners of CMP-NeuAc are described. These compounds are substrates for enzymatic glycosylation.
Novel Solid-phase Synthesis of Branched Oligoribonucleotides, including a Substrate for the RNA Debranching Enzyme
Sproat, Brian S.,Beijer, Barbro,Groetli, Morten,Ryder, Ursula,Morand, Kenneth L.,Lamond, Angus I.
, p. 419 - 432 (2007/10/02)
An effective new route for synthesizing branched oligoribionucleotides in the solid phase in the 5' to 3' direction has been developed.This required the synthesis of reversed monomers, viz. protected nucleoside 5'-phosphoramidites bearing 2'-O-Fpmp and 3'
