N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide

Base Information

Chemical Name:N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide
CAS No.:1394939-75-3
Molecular Formula:C₂₂H₂₀BrF₃N₂O₄S₂
Molecular Weight:577.443
Hs Code.:

Synonyms:N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide

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Chemical Property of N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide

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Technology Process of N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide

There total 11 articles about N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1394939-73-1
2,5-difluoro-N-{2-fluoro-3-[2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide

: 1394939-75-3
N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: 2,5-difluoro-N-{2-fluoro-3-[2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide; With sodium acetate; acetic acid;

With bromine; at 20 ℃;

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1394939-75-3
N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / ethylene glycol / 6 h / 120 °C / Inert atmosphere

4.1: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

5.1: pyridinium perbromide hydrobromide / tetrahydrofuran / 1 h / Reflux

6.1: ethanol / 1 h / 60 °C

7.1: sodium acetate; acetic acid

7.2: 20 °C

With pyridine; hydrogenchloride; pyridinium perbromide hydrobromide; water; sodium acetate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethylene glycol; 3.1: Heck Reaction;

Reference yield:

: 26120-86-5
2,5-difluorobenzenesulfonyl chloride

: 1394939-75-3
N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / ethylene glycol / 6 h / 120 °C / Inert atmosphere

4.1: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

5.1: pyridinium perbromide hydrobromide / tetrahydrofuran / 1 h / Reflux

6.1: ethanol / 1 h / 60 °C

7.1: sodium acetate; acetic acid

7.2: 20 °C

With pyridine; hydrogenchloride; pyridinium perbromide hydrobromide; water; sodium acetate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethylene glycol; 3.1: Heck Reaction;