3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite>

Base Information

• Chemical Name: 3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite>
• CAS No.: 156046-19-4
• Molecular Formula: C₅₃H₅₇N₈O₁₁P
• Molecular Weight: 1013.06
• Mol file: 156046-19-4.mol

Synonyms:3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite>

Chemical Property of 3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite>

There total 4 articles about 3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane (108787-34-4) + 3'-deoxy-5'-O-monomethoxytrityl-6-N-[2-(4-nitrophenyl)-ethoxycarbonyl]-adenosine (97776-92-6) → 3'-deoxy-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite> (156046-19-4)

Guidance literature:

With 1H-tetrazole; In acetonitrile; for 2h; Ambient temperature;

DOI:10.1002/hlca.19940770707

Reference yield:

2-(4-nitrophenyl)ethanol (100-27-6) → 3'-deoxy-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite> (156046-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1: PCl₃ / diethyl ether / 1.) -5 deg C, 15 min; 2.) r.t., 1.5 h;

2: diethyl ether / 1.) -10 deg C, 15 min; 2.) r.t., 16 h;

3: 89 percent / 1H-tetrazole / acetonitrile / 1.33 h / Ambient temperature

With 1H-tetrazole; phosphorus trichloride; In diethyl ether; acetonitrile;

DOI:10.1002/hlca.19940770104

Reference yield:

2-(4-nitrophenyl)ethyl chloride (20264-95-3) → 3'-deoxy-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite> (156046-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 1.) -10 deg C, 15 min; 2.) r.t., 16 h;

2: 89 percent / 1H-tetrazole / acetonitrile / 1.33 h / Ambient temperature

With 1H-tetrazole; In diethyl ether; acetonitrile;

DOI:10.1002/hlca.19940770104

upstream raw materials:

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane

3'-deoxy-5'-O-monomethoxytrityl-6-N-[2-(4-nitrophenyl)-ethoxycarbonyl]-adenosine

2-(4-nitrophenyl)ethanol

2-(4-nitrophenyl)ethyl chloride

Downstream raw materials:

3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-adenylic acid 2-{[6-(dibenzoylamino)-9H-purin-9-yl]methoxy}ethyl 2-(4-nitrophenyl)ethyl ester

3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>->5'>-2'-O-(2-dansylethoxycarbonyl)-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine