N-[2-(4-methoxyphenyl)ethyl]-1-(6-chloropyridin-2-yl)cyclobutanecarboxamide

Base Information

Chemical Name:N-[2-(4-methoxyphenyl)ethyl]-1-(6-chloropyridin-2-yl)cyclobutanecarboxamide
CAS No.:1190644-34-8
Molecular Formula:C₁₉H₂₁ClN₂O₂
Molecular Weight:344.841
Hs Code.:

Synonyms:N-[2-(4-methoxyphenyl)ethyl]-1-(6-chloropyridin-2-yl)cyclobutanecarboxamide

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Chemical Property of N-[2-(4-methoxyphenyl)ethyl]-1-(6-chloropyridin-2-yl)cyclobutanecarboxamide

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Technology Process of N-[2-(4-methoxyphenyl)ethyl]-1-(6-chloropyridin-2-yl)cyclobutanecarboxamide

There total 3 articles about N-[2-(4-methoxyphenyl)ethyl]-1-(6-chloropyridin-2-yl)cyclobutanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.6%

: 1190644-33-7
1-(6-chloropyridin-2-yl)cyclobutanecarboxylic acid hydrochloride

: 55-81-2
4-Methoxyphenethylamine

: 1190644-34-8
N-[2-(4-methoxyphenyl)ethyl]-1-(6-chloropyridin-2-yl)cyclobutanecarboxamide

Guidance literature:: 1-(6-chloropyridin-2-yl)cyclobutanecarboxylic acid hydrochloride; 4-Methoxyphenethylamine; With dmap; In dichloromethane; at 20 ℃; for 0.5h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 75279-60-6
2-(6-chloropyridin-2-yl)acetonitrile

: 1190644-34-8
N-[2-(4-methoxyphenyl)ethyl]-1-(6-chloropyridin-2-yl)cyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / N-benzyl-N,N,N-triethylammonium chloride / dichloromethane; water / 20 °C

2.1: hydrogenchloride; water / 0.5 h / 100 °C / Microwave irradiation

3.1: dmap / dichloromethane / 0.5 h / 20 °C

3.2: 0 - 20 °C

With hydrogenchloride; dmap; water; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; water;

Reference yield:

: 1190644-32-6
1-(6-chloropyridin-2-yl)cyclobutanecarbonitrile

: 1190644-34-8
N-[2-(4-methoxyphenyl)ethyl]-1-(6-chloropyridin-2-yl)cyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / 0.5 h / 100 °C / Microwave irradiation

2.1: dmap / dichloromethane / 0.5 h / 20 °C

2.2: 0 - 20 °C

With hydrogenchloride; dmap; water; In dichloromethane;