2,5-diethynylbenzaldehyde

Base Information

Chemical Name:2,5-diethynylbenzaldehyde
CAS No.:1263055-18-0
Molecular Formula:C₁₁H₆O
Molecular Weight:154.168
Hs Code.:

Synonyms:2,5-diethynylbenzaldehyde

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Chemical Property of 2,5-diethynylbenzaldehyde

Chemical Property:

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Technology Process of 2,5-diethynylbenzaldehyde

There total 8 articles about 2,5-diethynylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 885693-79-8
2,5-bis((trimethylsilyl)ethynyl)benzaldehyde

: 1263055-18-0
2,5-diethynylbenzaldehyde

Guidance literature:: With methanol; potassium carbonate; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1016/j.tet.2010.11.012

Reference yield:

: 689291-89-2
5-bromo-2-iodobenzaldehyde

: 1263055-18-0
2,5-diethynylbenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 60 °C / Inert atmosphere

2: methanol; potassium carbonate / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In tetrahydrofuran; 1: Sonogashira coupling;
DOI:10.1016/j.tet.2010.11.012

Reference yield:

: 181765-86-6
5-bromo-2-iodo-benzoic acid methyl ester

: 1263055-18-0
2,5-diethynylbenzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: dipyridinium dichromate / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 60 °C / Inert atmosphere

4.1: methanol; potassium carbonate / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dipyridinium dichromate; diisobutylaluminium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; 3.1: Sonogashira coupling;
DOI:10.1016/j.tet.2010.11.012