689291-89-2

Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-2-IODOBENZALDEHYDE is used as a synthetic intermediate for the preparation of aza-fused polycyclic quinolines, which are important scaffolds in the development of new pharmaceutical agents. These aza-fused polycyclic quinolines can exhibit a range of biological activities, making them potential candidates for the treatment of various diseases.
Used in Organic Synthesis:
5-BROMO-2-IODOBENZALDEHYDE is used as a key building block in the synthesis of oxoindenopyrroles, a class of compounds with potential applications in various fields, including materials science and medicinal chemistry. The synthesis of these compounds is achieved through copper-catalyzed tandem cycloaddition and coupling reactions.
Used in Chemical Research:
In the field of chemical research, 5-BROMO-2-IODOBENZALDEHYDE is employed as a starting material for the development of new synthetic methodologies and the exploration of novel chemical reactions. Its unique structural features allow chemists to investigate new ways to construct complex organic molecules and gain insights into the underlying reaction mechanisms.
Used in Material Science:
5-BROMO-2-IODOBENZALDEHYDE can be utilized in the synthesis of new materials with potential applications in various industries, such as electronics, optoelectronics, and energy storage. The incorporation of halogenated aromatic moieties into these materials can lead to improved properties, such as enhanced stability, solubility, and electronic characteristics.
Overall, 5-BROMO-2-IODOBENZALDEHYDE is a versatile and valuable compound with a wide range of applications in various industries, including pharmaceuticals, organic synthesis, chemical research, and material science. Its unique structural features and synthetic utility make it an important building block for the development of new molecules and materials with potential applications in various fields.

InChI:InChI=1/C7H4BrIO/c8-6-1-2-7(9)5(3-6)4-10/h1-4H

Upstream product

• 199786-58-8 (5-bromo-2-iodo-phenyl)-methanol 
• 181765-86-6 5-bromo-2-iodo-benzoic acid methyl ester 
• 21740-00-1 5-bromo-2-iodo-benzoic acid 
• 118-92-3 anthranilic acid 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 116632-39-4 2-methyl-4-bromoiodobenzene 
• 450412-27-8 4-bromo-1-iodobenzoic acid ethyl ester 
• 88-67-5 2-Iodobenzoic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 

Downstream Products

• 3096-56-8 2-bromofluoren-9-one 
• 1038395-08-2 1,4-bis(5-bromo-2-iodostyryl)benzene 
• 1038395-11-7 5-bromo-2-((triisopropylsilyl)ethynyl)benzaldehyde 
• 1175525-90-2 (5-Bromo-2-iodo-benzyl)-ethyl-amine 
• 1222168-93-5 4-bromo-2-(diethoxymethyl)-1-iodobenzene 
• 1038395-09-3 C₄₂H₅₀Si₄ 
• 1038395-10-6 C₃₀H₁₈ 
• 1038395-15-1 C₆₂H₄₂O₈ 
• 1263055-18-0 2,5-diethynylbenzaldehyde 
• 1263055-20-4 C₂₇H₁₈O₅ 
• 1263055-24-8 2-((triisopropylsilyl)ethynyl)-5-((trimethylsilyl)ethynyl)benzaldehyde 
• 1263055-26-0 5-ethynyl-2-((triisopropylsilyl)ethynyl)benzaldehyde 
• 1263055-28-2 methyl 2-((3-formyl-4-((triisopropylsilyl)ethynyl)phenyl)ethynyl)benzoate 
• 1263055-30-6 methyl 2-((4-ethynyl-3-formylphenyl)ethynyl)benzoate 

Relevant academic research and scientific papers

INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE - SYNTHESIS AND USE THEREOF FOR TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AND LYMPHOMA

The present invention relates to new compounds of general formula I, their synthesis, their pharmaceutically acceptable salts, and their use in treatment of T-cell acute lymphoblastic leukemia and lymphoma.

One-Pot Synthesis and Conformational Analysis of Six-Membered Cyclic Iodonium Salts

Two one-pot procedures for the construction of carbon-bridged diaryliodonium triflates and tetrafluoroborates are described. Strong Br?nsted acids enable the effective Friedel-Crafts alkylation with diversely substituted o-iodobenzyl alcohol derivatives, providing diphenylmethane scaffolds, which are subsequently oxidized and cyclized to the corresponding dibenzo[b,e]iodininium salts. Based on NMR investigations and density functional theory (DFT) calculations, we could verify the so-far-undescribed existence of two stable isomers in cyclic iodonium salts substituted with aliphatic side chains in the carbon bridge.

Iodolopyrazolium Salts: Synthesis, Derivatizations, and Applications

The synthesis of iodolopyrazolium triflates via an oxidative cyclization of 3-(2-iodophenyl)-1H-pyrazoles is described. The reaction is characterized by a broad substrate scope, and various applications of these novel cyclic iodolium salts acting as useful synthetic intermediates are demonstrated, in particular in site-selective ring openings. This was finally applied to generate derivatives of the anti-inflammatory drug celecoxib. Their application as highly active halogen-bond donors is shown as well.

ISOQUINOLINE DERIVATIVES AS PERK INHIBITORS

The invention is directed to substituted isoquinoline derivatives and uses thereof. Specifically, the invention is directed to compounds according to Formula I and the use of compounds of Formula (I) in treating disease states: (I) wherein R1,

Cu-Catalyzed Enantioselective Ring Opening of Cyclic Diaryliodoniums toward the Synthesis of Chiral Diarylmethanes

A Cu-catalyzed enantioselective desymmetrizing ring-opening reaction of six-membered cyclic diaryliodonium salts with carboxylic acids or thioacids is reported for the facile access to chiral diarylmethanes. A Cu/[cyclopropyl bis(oxazoline)] catalyst well

Intramolecular Pd-Catalyzed Arylation of 1-Amidosugars: A New Route to N-Glycosyl Quinolin-2-ones

The synthesis of N-glycosylated quinolin-2-ones via an intramolecular N-arylation of glycosylamides is reported. The coupling involves the use of only Pd(OAc)2 as the catalyst and nBu4NOAc as the base in 1,4-dioxane. This versatile approach allows the synthesis of various N-glycosylated quinolin-2-ones with exclusive α or β selectivity.

Intriguing substituent effect in modified Hoveyda-Grubbs metathesis catalysts incorporating a chelating iodo-benzylidene ligand

A series of modified Hoveyda-Grubbs catalysts incorporating a chelating iodo-benzylidene ligand were prepared and characterized. The presence of electron-withdrawing ring substituents in the para position to the iodide was found to decrease the catalytic activity, revealing that dissociation of the Ru...I-Ar bond is not the rate-determining step.

Palladium-catalyzed insertion of N-tosylhydrazones for the synthesis of isoindolines

Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with α,β-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration of a wide range of functional groups, (2) easy to handle and with mild conditions, (3) enriches the isoindoline family, (4) two new bonds form in one step.

OPE/OPV H-mers: Synthesis, electronic properties, and spectroscopic responses to binding with transition metal ions

A new type of structurally defined H-shaped OPE/OPV co-oligomers (termed H-mers) functionalized with various donor and/or acceptor end groups was synthesized by iterative Sonogashira coupling and Horner-Wadsworth-Emmons (HWE) reactions. Electronic substitution effects on the H-mer backbone were investigated by UV-vis absorption and fluorescence spectroscopy. Some H-mers were found to show spectral responses upon binding to an acid (TFA) or transition metal ions, revealing the applicability of H-mers in the field of chromophore and fluorophore based chemosensors.

Functionalized dibenzoborepins as components of small molecule and polymeric π-conjugated electronic materials

We present the synthesis and characterization of dibenzo[b,f]borepins (DBBs) functionalized at the para and meta position with respect to the boron center in order to understand how regiochemical issues influence photophysical and electrochemical properti