689291-89-2

Basic information

• Product Name: 5-BROMO-2-IODOBENZALDEHYDE
• Synonyms: 5-BROMO-2-IODOBENZALDEHYDE
• CAS NO: 689291-89-2
• Molecular Formula: C₇H₄BrIO
• Molecular Weight: 310.91
• Mol File: 689291-89-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 89-90 ºC
• Boiling Point: 312.152°C at 760 mmHg
• Flash Point: 142.585°C
• Appearance: /
• Density: 2.231
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.696
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-BROMO-2-IODOBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-IODOBENZALDEHYDE(689291-89-2)
• EPA Substance Registry System: 5-BROMO-2-IODOBENZALDEHYDE(689291-89-2)

Safety Data

• Hazardous Substances Data: 689291-89-2(Hazardous Substances Data)

Usage

Uses

5-Bromo-2-iodobenzaldehyde is a useful synthetic intermediate. It is used to prepare aza-fused polycyclic quinolines via copper-catalyzed cascade intermolecular condensation. It is also used in the synthesis of oxoindenopyrroles via copper-catalyzed tandem cycloaddition and coupling of iodoarylynones with isocyanides.

InChI:InChI=1/C7H4BrIO/c8-6-1-2-7(9)5(3-6)4-10/h1-4H

Upstream product

• 450412-27-8 4-bromo-1-iodobenzoic acid ethyl ester 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 88-67-5 2-Iodobenzoic acid 
• 116632-39-4 2-methyl-4-bromoiodobenzene 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 118-92-3 anthranilic acid 
• 21740-00-1 5-bromo-2-iodo-benzoic acid 
• 181765-86-6 5-bromo-2-iodo-benzoic acid methyl ester 
• 199786-58-8 (5-bromo-2-iodo-phenyl)-methanol 

Downstream Products

• 3096-56-8 2-bromofluoren-9-one 
• 1257065-29-4 4-[1-(5-bromo-2-iodophenyl)methylidene]-2,2,5,5-tetramethyldihydrofuran-3-one 
• 1278522-46-5 (Z)-1,2-bis(5-bromo-2-iodophenyl)ethene 
• 1283638-40-3 C₁₆H₁₁BrO₂ 
• 1279129-98-4 2,8-bis(trimethylsilylethynyl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-99-5 3,7-bis(trimethylsilylethynyl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-81-5 2,8-diethynyl-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-83-7 3,7-diethynyl-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-77-9 2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-80-4 2,8-di(thiophen-2-yl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-89-3 2,8-di([2,2'-bithiophen]-5-yl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1318897-45-8 (7-bromo-3-isoquinolinyl)methanol 

Relevant articles and documents

INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE - SYNTHESIS AND USE THEREOF FOR TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AND LYMPHOMA

The present invention relates to new compounds of general formula I, their synthesis, their pharmaceutically acceptable salts, and their use in treatment of T-cell acute lymphoblastic leukemia and lymphoma.

One-Pot Synthesis and Conformational Analysis of Six-Membered Cyclic Iodonium Salts

Two one-pot procedures for the construction of carbon-bridged diaryliodonium triflates and tetrafluoroborates are described. Strong Br?nsted acids enable the effective Friedel-Crafts alkylation with diversely substituted o-iodobenzyl alcohol derivatives, providing diphenylmethane scaffolds, which are subsequently oxidized and cyclized to the corresponding dibenzo[b,e]iodininium salts. Based on NMR investigations and density functional theory (DFT) calculations, we could verify the so-far-undescribed existence of two stable isomers in cyclic iodonium salts substituted with aliphatic side chains in the carbon bridge.

ISOQUINOLINE DERIVATIVES AS PERK INHIBITORS

The invention is directed to substituted isoquinoline derivatives and uses thereof. Specifically, the invention is directed to compounds according to Formula I and the use of compounds of Formula (I) in treating disease states: (I) wherein R1,