2-(phenylmethyl-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino)ethylcarbamic acid tert-butyl ester

Base Information

Chemical Name:2-(phenylmethyl-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino)ethylcarbamic acid tert-butyl ester
CAS No.:190953-87-8
Molecular Formula:C₂₇H₃₄N₆O₂
Molecular Weight:474.606
Hs Code.:

Synonyms:2-(phenylmethyl-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino)ethylcarbamic acid tert-butyl ester

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Chemical Property of 2-(phenylmethyl-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino)ethylcarbamic acid tert-butyl ester

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Technology Process of 2-(phenylmethyl-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino)ethylcarbamic acid tert-butyl ester

There total 4 articles about 2-(phenylmethyl-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino)ethylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 190953-86-7
2-<3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propylamino>ethylcarbamic acid tert-butyl ester

: 190953-87-8
2-(phenylmethyl-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino)ethylcarbamic acid tert-butyl ester

Guidance literature:: With sodium cyanoborohydride; benzaldehyde; acetic acid; In methanol;

Reference yield: 85.0%

: 100-52-7
benzaldehyde

: 190953-86-7
2-<3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propylamino>ethylcarbamic acid tert-butyl ester

: 190953-87-8
2-(phenylmethyl-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino)ethylcarbamic acid tert-butyl ester

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; for 22h; Ambient temperature;
DOI:10.1021/jm980569z

Reference yield:

: 57260-73-8
N-BOC-1,2-diaminoethane

: 190953-87-8
2-(phenylmethyl-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino)ethylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) MeSO₂Cl, Et₃N, 2.) K₂CO₃, NaI / 1.) THF, 90 min, 2.) THF, i-PrOH, reflux, 9 h

2: 85 percent / AcOH, NaBH₃CN / methanol / 22 h / Ambient temperature

With sodium cyanoborohydride; potassium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; sodium iodide; In methanol;
DOI:10.1021/jm980569z