(4-((5-bromo-2-chlorophenyl)methyl-d2)phenoxy)(tertbutyl)dimethylsilane

Base Information

Chemical Name:(4-((5-bromo-2-chlorophenyl)methyl-d2)phenoxy)(tertbutyl)dimethylsilane
CAS No.:1548877-02-6
Molecular Formula:C₁₉H₂₄BrClOSi
Molecular Weight:413.826
Hs Code.:

Synonyms:(4-((5-bromo-2-chlorophenyl)methyl-d2)phenoxy)(tertbutyl)dimethylsilane

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Chemical Property of (4-((5-bromo-2-chlorophenyl)methyl-d2)phenoxy)(tertbutyl)dimethylsilane

Chemical Property:

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Technology Process of (4-((5-bromo-2-chlorophenyl)methyl-d2)phenoxy)(tertbutyl)dimethylsilane

There total 4 articles about (4-((5-bromo-2-chlorophenyl)methyl-d2)phenoxy)(tertbutyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1204219-40-8
4-((5-bromo-2-chlorophenyl)methyl-d2)phenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1548877-02-6
(4-((5-bromo-2-chlorophenyl)methyl-d2)phenoxy)(tertbutyl)dimethylsilane

Guidance literature:: With triethylamine; In acetonitrile; at 5 - 15 ℃; for 2h;
DOI:10.1021/jm401780b

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 1548877-02-6
(4-((5-bromo-2-chlorophenyl)methyl-d2)phenoxy)(tertbutyl)dimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 10 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 1 h / -5 - 20 °C / Inert atmosphere

2.2: 2 h / -5 - 0 °C / Inert atmosphere

3.1: aluminum (III) chloride; sodium borodeuteride / tetrahydrofuran / 18 h / 5 - 20 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / -10 - 0 °C / Inert atmosphere

5.1: triethylamine / acetonitrile / 2 h / 5 - 15 °C

With aluminum (III) chloride; sodium borodeuteride; oxalyl dichloride; boron tribromide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm401780b

Reference yield:

: 21900-52-7
5-bromo-2-chloro-benzoyl chloride

: 1548877-02-6
(4-((5-bromo-2-chlorophenyl)methyl-d2)phenoxy)(tertbutyl)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / dichloromethane / 1 h / -5 - 20 °C / Inert atmosphere

1.2: 2 h / -5 - 0 °C / Inert atmosphere

2.1: aluminum (III) chloride; sodium borodeuteride / tetrahydrofuran / 18 h / 5 - 20 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / -10 - 0 °C / Inert atmosphere

4.1: triethylamine / acetonitrile / 2 h / 5 - 15 °C

With aluminum (III) chloride; sodium borodeuteride; boron tribromide; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm401780b