N⁴-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N⁴-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
• CAS No.: 1369493-27-5
• Molecular Formula: C₁₂H₁₀BrN₅
• Molecular Weight: 304.149
• Mol file: 1369493-27-5.mol

Synonyms:N⁴-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Chemical Property of N⁴-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

There total 1 articles about N⁴-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (84955-31-7) + m-Bromoaniline (591-19-5) → N4-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1369493-27-5)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; for 10h; Reflux;

DOI:10.1080/14756366.2017.1376666

Reference yield: 47.0%

N4-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1369493-27-5) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → N(4)-(3-bromophenyl)-7-(4-chlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1369493-19-5)

Guidance literature:

N⁴-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

1-Chloro-4-(chloromethyl)benzene; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2012.01.029

Reference yield: 36.0%

N4-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1369493-27-5) + benzyl bromide (100-39-0) → 7-benzyl-N(4)-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1369493-16-2)

Guidance literature:

N⁴-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2012.01.029

upstream raw materials:

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

m-Bromoaniline

Downstream raw materials:

7-biphenyl-4-ylmethyl-N⁽⁴⁾-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

N⁽⁴⁾-(3-bromophenyl)-7-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

7-benzyl-N⁽⁴⁾-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

N⁽⁴⁾-(3-bromophenyl)-7-(2-chlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine