{2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol

Base Information

• Chemical Name: {2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol
• CAS No.: 244254-86-2
• Molecular Formula: C₃₀H₃₂O₂Si
• Molecular Weight: 452.668
• Mol file: 244254-86-2.mol

Synonyms:{2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol

Chemical Property of {2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol

There total 4 articles about {2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-benzoic acid 2-[(R)-(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester (244254-85-1) → {2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol (244254-86-2)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃;

DOI:10.1016/S0957-4166(99)00231-1

Reference yield:

methyl o-benzoylbenzoate (606-28-0) → {2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol (244254-86-2)

Guidance literature:

Multi-step reaction with 4 steps

1: LiAlH₄ / diethyl ether

2: 30 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 48 h / 20 °C

3: 97 percent / imidazole / dimethylformamide / 20 °C

4: 81 percent / K₂CO₃ / methanol / 20 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; potassium carbonate; dicyclohexyl-carbodiimide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(99)00231-1

Reference yield:

(2-hydroxymethylphenyl)phenylmethanol (1586-01-2) → {2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol (244254-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 30 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 48 h / 20 °C

2: 97 percent / imidazole / dimethylformamide / 20 °C

3: 81 percent / K₂CO₃ / methanol / 20 °C

With 1H-imidazole; dmap; potassium carbonate; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(99)00231-1

upstream raw materials:

4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid 2-[(R)-(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester

methyl o-benzoylbenzoate

(2-hydroxymethylphenyl)phenylmethanol

4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid 2-((R)-hydroxy-phenyl-methyl)-benzyl ester

Downstream raw materials:

methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester

(R)-o-methylbenzhydrol

tert-butyl-diphenyl-(phenyl-o-tolyl-methoxy)-silane