1586-01-2

Basic information

• Product Name: 1,2-Benzenedimethanol, a-phenyl-
• CAS NO: 1586-01-2
• Molecular Formula: C14H14O2
• Molecular Weight: 214.264
• Mol File: 1586-01-2.mol

Chemical Properties

• CAS DataBase Reference: 1,2-Benzenedimethanol, a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzenedimethanol, a-phenyl-(1586-01-2)
• EPA Substance Registry System: 1,2-Benzenedimethanol, a-phenyl-(1586-01-2)

Safety Data

• Hazardous Substances Data: 1586-01-2(Hazardous Substances Data)

Usage

Usage

Building block for polymers and resins
Epoxy resins
Polycarbonate plastics

Application

Crosslinking agent in thermosetting polymers

Application

Flame retardant in some cases

Potential applications

Pharmaceuticals, dye intermediate

Safety precautions

Skin and respiratory irritant
Handle with care
Use in well-ventilated areas
Wear appropriate personal protective equipment

Upstream product

• 606-28-0 methyl o-benzoylbenzoate 
• 100-51-6 benzyl alcohol 
• 613-94-5 benzoic acid hydrazide 
• 3232-37-9 salicylaldehyde benzoylhydrazone 
• 16780-82-8 2-benzoylbenzaldehyde 
• 87-41-2 2-benzofuran-1(3H)-one 
• 85-52-9 2-Benzoylbenzoic acid 
• 5398-11-8 3-phenylphthalide 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 90-02-8 salicylaldehyde 
• 3381-87-1 2-benzyloxybenzyl alcohol 
• 16859-59-9 3-hydroxy-1(3H)-isobenzofuranone 
• 108-86-1 bromobenzene 
• 17158-47-3 7,7-dimethyl-7-silabicyclo[4.2.0]octa-1⁽⁶⁾,2,4-triene 

Downstream Products

• 21464-37-9 bromophenylmethyl-1 bromomethyl-2 benzene 
• 125593-17-1 Benzoic acid 2-(hydroxy-phenyl-methyl)-benzyl ester 
• 244254-84-0 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid 2-((R)-hydroxy-phenyl-methyl)-benzyl ester 
• 1517-59-5 (R)-o-methylbenzhydrol 
• 244254-88-4 tert-butyl-diphenyl-(phenyl-o-tolyl-methoxy)-silane 
• 244254-86-2 {2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol 
• 244254-87-3 methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester 
• 244254-85-1 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid 2-[(R)-(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester 
• 21464-33-5 4-phenyl-3-propionyl-3,4-dihydro-1H-benzo[d][1,2]oxazine 
• 21464-30-2 3-benzyl-4-phenyl-3,4-dihydro-1H-benzo[d][1,2]oxazine 
• 21464-31-3 3-benzoyl-4-phenyl-3,4-dihydro-1H-benzo[d][1,2]oxazine 
• 21464-36-8 4-phenyl-1,4-dihydro-benzo[d][1,2]oxazine-3-carboxylic acid ethyl ester 
• 21464-25-5 1-carbamoyloxy-2-(4-phenyl-1,4-dihydro-benzo[d][1,2]oxazin-3-yl)-ethane 
• 21464-32-4 3-[(4-isobutyl-phenyl)-acetyl]-4-phenyl-3,4-dihydro-1H-benzo[d][1,2]oxazine 

Relevant articles and documents

Synthesis of 1,2-phenylenedimethanols by base-promoted reduction of isobenzofuran-1(3H)-ones with silane

An efficient method for preparation of substituted 1,2-phenylenedimethanols and aliphatic 1,4-diols that are valuable intermediates in organic synthesis, has been developed by the base-promoted reduction of isobenzofuran-1(3H)-ones and γ-lactones with silane under mild conditions. Compared with traditional procedures using stoichiometric amounts of metal hydrides and alkyl reductants, the present method avoids the use of sensitive reagents and is operationally simple and a broad variety of functional groups are tolerated.

A synthetic O-methanol derivatives (by machine translation)

The invention belongs to the technical field of chemical engineering, in particular to a synthetic O-methanol derivatives. The invention to phthalide as raw materials, alkali and under the effects of the compound silicane, through reducing the ring-opening reaction, to prepare the O-methanol. The method of the invention raw materials are easy, simple operation, strong reaction selectivity, high product yield, mild reaction conditions; synthetic mono substituted O b methanol derivatives high quality, functional group compatibility. (by machine translation)

Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes: Application to the synthesis of escitalopram

An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed. In this novel route, o-aroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. The mild and general st

Neighboring lithium-assisted [1,2]-wittig rearrangement: Practical access to diarylmethanol-based 1,4-diols and optically active binol derivatives with axial and sp3-central chirality

A facile and practical methodology for the synthesis of synthetically useful diarylmethanol-based 1,4-diols and enantiomerically pure BINOL-derived diols with axial and sp3-central chirality has been developed through neighboring lithium-promot

Systematic investigations on the reduction of 4-aryl-4-oxoesters to 1-aryl-1,4-butanediols with methanolic sodium borohydride

4-Aryl-4-oxoesters undergo facile reduction of both the keto and the ester groups with methanolic NaBH4 at room temperature to yield the corresponding 1-aryl-1,4-butanediols whereas 4-alkyl-4-oxoesters furnish the corresponding 1,4-butanolides via selective reduction of the keto moiety. Results of a detailed and systematic investigation of the reaction are described.

Nickel-catalyzed reactions of silacyclobutanes with aldehydes: Ring opening and ring expansion reaction

The nickel-catalyzed ring opening reaction of silacyclobutanes with aldehydes affords the corresponding alkoxyallylsilanes. In contrast, the ring expansion reaction of benzosilacyclobutene with aldehydes occurs under nickel catalysis to give oxasilacycloh

METHOD OF SUBSTITUENT INTRODUCTION THROUGH HALOGEN-METAL EXCHANGE REACTION

A method of exchanging a halogen atom of a halide, which has a group containing an acidic proton and in which one or more halogen atom(s) is/are substituted on a carbon atom of the carbon-carbon double bond, with a metal atom by halogen-metal-exchange reaction and introducing an electrophilic reagent into the carbon atom to which the metal atom is attached. The above method is an industrially excellent method of introducing a substituent by halogen-metal exchange reaction.

Non-cryogenic metalation of aryl bromides bearing proton donating groups: Formation of a stable magnesio-intermediate

Bromine-metal exchange of o-bromobenzoic acid (1) with Bu2Mg followed by n-BuLi was successfully carried out at non-cryogenic temperature (>-20°C), and gave a stabilized metal species which smoothly reacted with several electrophiles. This methodology expanded to several other bromides bearing proton donating groups (PDGs).

Enantioresolution by the chiral phthalic acid method: Absolute configurations of (2-methylphenyl)phenylmethanol and related compounds

Racemic (2-hydroxymethylphenyl)phenylmethanol 5 was enantioresolved by the chiral phthalic acid method using acid-amide 2, and the absolute configurations of (-)-(2-methylphenyl)phenylmethanol 3 and related o-substituted diphenylmethanol derivatives were unambiguously determined by X-ray crystallography and chemical correlation.

DTBB-catalysed lithiation of chlorinated benzylic chlorides, alcohols, thiols or amines

The reaction of chlorinated benzyl chlorides (I) with an excess of lithium powder and a catalytic amount of DTBB (4 mol %) in the presence of different electrophiles [Pr(i)CHO, Bu(t)CHO, Et2CO, (CH2)5CO, PhCOMe, Me3/