o-Hydroxymethylbenzhydrol

Base Information

• Chemical Name: o-Hydroxymethylbenzhydrol
• CAS No.: 1586-01-2
• Molecular Formula: C14H14O2
• Molecular Weight: 214.264
• DSSTox Substance ID: DTXSID501304618
• Nikkaji Number: J1.802.900F
• Mol file: 1586-01-2.mol

Synonyms:o-hydroxymethylbenzhydrol;2-hydroxymethylbenzhydrol;alpha-Phenyl-benzene dimethanol;SCHEMBL6444765;DGDHXBHBKBNKJI-UHFFFAOYSA-N;DTXSID501304618;alpha1-Phenyl-1,2-benzenedimethanol;1586-01-2;(2-(Hydroxymethyl)phenyl)(phenyl)methanol

Chemical Property of o-Hydroxymethylbenzhydrol

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 214.099379685
• Heavy Atom Count: 16
• Complexity: 199

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2CO)O

Technology Process of o-Hydroxymethylbenzhydrol

There total 23 articles about o-Hydroxymethylbenzhydrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzaldehyde (100-52-7) + Lithium-2-lithiobenzylalkoholat → (2-hydroxymethylphenyl)phenylmethanol (1586-01-2)

Guidance literature:

In pentane; -30 degC -> room temp.;

Reference yield: 91.0%

4,5-benzo-1,1-dimethyl-2-oxa-3-phenyl-1-silacyclohexene → (2-hydroxymethylphenyl)phenylmethanol (1586-01-2)

Guidance literature:

With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate; In tetrahydrofuran; methanol; at 20 ℃; for 24h;

DOI:10.1021/ol0527577

Reference yield: 91.0%

2-benzyloxybenzyl alcohol (3381-87-1) → (2-hydroxymethylphenyl)phenylmethanol (1586-01-2)

Guidance literature:

With (2-methylpropyl)lithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201003111

upstream raw materials:

2-Benzoylbenzoic acid

2-benzofuran-1(3H)-one

methyl o-benzoylbenzoate

3-phenylphthalide

Downstream raw materials:

bromophenylmethyl-1 bromomethyl-2 benzene

2-Benzoylbenzoic acid

2-methylbenzhydrol

2-Benzylbenzoic acid