2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<(tert-butoxycarbonyl)amino>oxazole

Base Information

Chemical Name:2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<(tert-butoxycarbonyl)amino>oxazole
CAS No.:127086-88-8
Molecular Formula:C₄₃H₄₇N₃O₈
Molecular Weight:733.861
Hs Code.:

2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<(tert-butoxycarbonyl)amino>oxazole

Synonyms:2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<(tert-butoxycarbonyl)amino>oxazole

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Chemical Property of 2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<(tert-butoxycarbonyl)amino>oxazole

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Technology Process of 2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<(tert-butoxycarbonyl)amino>oxazole

There total 14 articles about 2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<(tert-butoxycarbonyl)amino>oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 34619-03-9
tert-butyldicarbonate

: 127086-87-7
2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-(trifluoroacetamido)oxazole

: 127086-88-8
2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<(tert-butoxycarbonyl)amino>oxazole

Guidance literature:: With 4-methyl-morpholine; dmap; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/ja00175a039

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 127086-88-8
2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<(tert-butoxycarbonyl)amino>oxazole

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / conc. H₂SO₄ / Heating

2: 90 percent / diethylazodicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

3: 99 percent / trifluoracetic acid / CH₂Cl₂ / Ambient temperature

4: 3.63 g / NaIO₄, RuCl₃ dihydrate / acetonitrile; CCl₄; H₂O / 2 h / 0 °C

5: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 0 deg C, 2.) 0 deg C, 4 h

6: 93 percent / trifluoroacetic acid / CH₂Cl₂ / 0 - 20 °C

7: 81 percent / DMAP, N-methylmorpholine / tetrahydrofuran / Ambient temperature

With 4-methyl-morpholine; dmap; ruthenium trichloride; sodium periodate; sulfuric acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ja00175a039

Reference yield:

: 41997-33-5
iso-propyl 4-hydroxyphenylacetate

: 127086-88-8
2-<1-(R)-(N-carbobenzyloxy-N-methylamino)-2(R)-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-<(tert-butoxycarbonyl)amino>oxazole

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / diethylazodicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

2: 99 percent / trifluoracetic acid / CH₂Cl₂ / Ambient temperature

3: 3.63 g / NaIO₄, RuCl₃ dihydrate / acetonitrile; CCl₄; H₂O / 2 h / 0 °C

4: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 0 deg C, 2.) 0 deg C, 4 h

5: 93 percent / trifluoroacetic acid / CH₂Cl₂ / 0 - 20 °C

6: 81 percent / DMAP, N-methylmorpholine / tetrahydrofuran / Ambient temperature

With 4-methyl-morpholine; dmap; ruthenium trichloride; sodium periodate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ja00175a039