1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine

Base Information

Chemical Name:1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine
CAS No.:1352805-49-2
Molecular Formula:C₁₅H₁₃ClFN₃
Molecular Weight:289.74
Hs Code.:

Synonyms:1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine

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Technology Process of 1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine

There total 8 articles about 1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1352805-48-1
tert-butyl {1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethyl}carbamate

: 1352805-49-2
1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 1352805-43-6
N-methoxy-N-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

: 1352805-49-2
1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / dichloromethane; methanol

2: methylmagnesium bromide; ammonium chloride / tetrahydrofuran

3: ammonium acetate; sodium cyanoborohydride / methanol; acetonitrile

4: triethylamine; sodium hydrogencarbonate / tetrahydrofuran

5: N-chloro-succinimide / N,N-dimethyl-formamide

6: hydrogenchloride / 1,4-dioxane

With pyridine; ammonium acetate; hydrogenchloride; N-chloro-succinimide; methylmagnesium bromide; ammonium chloride; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 136818-50-3
7-azaindole-2-carboxylic acid

: 1352805-49-2
1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / N,N-dimethyl-formamide

2: pyridine / dichloromethane; methanol

3: methylmagnesium bromide; ammonium chloride / tetrahydrofuran

4: ammonium acetate; sodium cyanoborohydride / methanol; acetonitrile

5: triethylamine; sodium hydrogencarbonate / tetrahydrofuran

6: N-chloro-succinimide / N,N-dimethyl-formamide

7: hydrogenchloride / 1,4-dioxane

With pyridine; ammonium acetate; hydrogenchloride; N-chloro-succinimide; methylmagnesium bromide; ammonium chloride; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;