(S)-2-Amino-N-(2-{2-[2-(4-aminomethyl-phenoxy)-ethoxy]-ethoxy}-ethyl)-3-methyl-butyramide

Base Information

Chemical Name:(S)-2-Amino-N-(2-{2-[2-(4-aminomethyl-phenoxy)-ethoxy]-ethoxy}-ethyl)-3-methyl-butyramide
CAS No.:1026026-69-6
Molecular Formula:C₁₈H₃₁N₃O₄
Molecular Weight:353.462
Hs Code.:

Synonyms:(S)-2-Amino-N-(2-{2-[2-(4-aminomethyl-phenoxy)-ethoxy]-ethoxy}-ethyl)-3-methyl-butyramide

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Chemical Property of (S)-2-Amino-N-(2-{2-[2-(4-aminomethyl-phenoxy)-ethoxy]-ethoxy}-ethyl)-3-methyl-butyramide

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Technology Process of (S)-2-Amino-N-(2-{2-[2-(4-aminomethyl-phenoxy)-ethoxy]-ethoxy}-ethyl)-3-methyl-butyramide

There total 6 articles about (S)-2-Amino-N-(2-{2-[2-(4-aminomethyl-phenoxy)-ethoxy]-ethoxy}-ethyl)-3-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6338-55-2
2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

: 1026026-69-6
(S)-2-Amino-N-(2-{2-[2-(4-aminomethyl-phenoxy)-ethoxy]-ethoxy}-ethyl)-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-hydroxybenzotriazole, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 24 h / Ambient temperature

2: pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

3: K₂CO₃, tetrabutylammonium iodide / dimethylsulfoxide / 4 h / 70 °C

4: hydroxyammonium chloride, aq. AcONa / ethanol / 1.5 h / 60 °C

5: formic acid, H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

With pyridine; formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm950641i

Reference yield:

: {(S)-1-[2-(2-{2-[4-(Hydroxyimino-methyl)-phenoxy]-ethoxy}-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester

: 1026026-69-6
(S)-2-Amino-N-(2-{2-[2-(4-aminomethyl-phenoxy)-ethoxy]-ethoxy}-ethyl)-3-methyl-butyramide

Guidance literature:: With formic acid; hydrogen; palladium on activated charcoal; In methanol; for 3h; under 760 Torr;
DOI:10.1021/jm950641i

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 1026026-69-6
(S)-2-Amino-N-(2-{2-[2-(4-aminomethyl-phenoxy)-ethoxy]-ethoxy}-ethyl)-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-hydroxybenzotriazole, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 24 h / Ambient temperature

2: pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

3: K₂CO₃, tetrabutylammonium iodide / dimethylsulfoxide / 4 h / 70 °C

4: hydroxyammonium chloride, aq. AcONa / ethanol / 1.5 h / 60 °C

5: formic acid, H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

With pyridine; formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm950641i