[2-(2-Amino-5-decyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[2-(2-Amino-5-decyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester
CAS No.:168965-86-4
Molecular Formula:C₂₄H₄₂N₂O₃
Molecular Weight:406.609
Hs Code.:

Synonyms:[2-(2-Amino-5-decyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [2-(2-Amino-5-decyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

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Technology Process of [2-(2-Amino-5-decyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

There total 11 articles about [2-(2-Amino-5-decyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 168965-85-3
{2-[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester

: 168965-86-4
[2-(2-Amino-5-decyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 10h; Ambient temperature;
DOI:10.1021/jm970704s

Reference yield:

: 64152-09-6
3-Methoxycarbonyl-4-nitrobenzoic acid

: 168965-86-4
[2-(2-Amino-5-decyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 91 percent / BH₃*methyl sulfide / tetrahydrofuran / 5 h / Heating

2: 94 percent / PCC, neutral activity I Al₂O₃ / CH₂Cl₂ / 18 h / 0 °C

3: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 40 min, 2.) THF, hexane, 0 deg C, 3.5 h

4: 82 percent / LiBH₄ / tetrahydrofuran / 17 h / 0 - 20 °C

5: NaH / toluene / 2 h / Ambient temperature

6: 77 percent / NaH / dimethylformamide / 16 h / Ambient temperature

7: conc. aq. HCl / acetic acid / 24 h / Heating

8: SOCl₂ / 30 h / Ambient temperature

9: CH₂Cl₂ / 18 h / Ambient temperature

10: 49 percent / LiBH₄ / tetrahydrofuran / 18.5 h / 0 - 20 °C

11: 92 percent / H₂ / 10percent Pd/C / ethanol / 10 h / Ambient temperature

With hydrogenchloride; aluminum oxide; lithium borohydride; n-butyllithium; thionyl chloride; dimethylsulfide borane complex; hydrogen; sodium hydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm970704s

Reference yield:

: 168965-80-8
[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-methanol

: 168965-86-4
[2-(2-Amino-5-decyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NaH / toluene / 2 h / Ambient temperature

2: 77 percent / NaH / dimethylformamide / 16 h / Ambient temperature

3: conc. aq. HCl / acetic acid / 24 h / Heating

4: SOCl₂ / 30 h / Ambient temperature

5: CH₂Cl₂ / 18 h / Ambient temperature

6: 49 percent / LiBH₄ / tetrahydrofuran / 18.5 h / 0 - 20 °C

7: 92 percent / H₂ / 10percent Pd/C / ethanol / 10 h / Ambient temperature

With hydrogenchloride; lithium borohydride; thionyl chloride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm970704s