{2-[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{2-[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester
CAS No.:168965-85-3
Molecular Formula:C₂₄H₃₈N₂O₅
Molecular Weight:434.576
Hs Code.:

Synonyms:{2-[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {2-[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {2-[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester

There total 8 articles about {2-[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 168965-84-2
2-tert-Butoxycarbonylamino-3-[5-((Z)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester

: 168965-85-3
{2-[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 18.5h;
DOI:10.1021/jm970704s

Reference yield:

: 168965-81-9
Toluene-4-sulfonic acid 5-((Z)-dec-1-enyl)-2-nitro-benzyl ester

: 168965-85-3
{2-[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / NaH / dimethylformamide / 16 h / Ambient temperature

2: conc. aq. HCl / acetic acid / 24 h / Heating

3: SOCl₂ / 30 h / Ambient temperature

4: CH₂Cl₂ / 18 h / Ambient temperature

5: 49 percent / LiBH₄ / tetrahydrofuran / 18.5 h / 0 - 20 °C

With hydrogenchloride; lithium borohydride; thionyl chloride; sodium hydride; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm970704s

Reference yield:

: 168965-82-0
2-Acetylamino-2-[5-((Z)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester

: 168965-85-3
{2-[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: conc. aq. HCl / acetic acid / 24 h / Heating

2: SOCl₂ / 30 h / Ambient temperature

3: CH₂Cl₂ / 18 h / Ambient temperature

4: 49 percent / LiBH₄ / tetrahydrofuran / 18.5 h / 0 - 20 °C

With hydrogenchloride; lithium borohydride; thionyl chloride; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jm970704s