(S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionic acid

Base Information

• Chemical Name: (S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionic acid
• CAS No.: 1003593-08-5
• Molecular Formula: C₃₁H₅₂N₂O₇
• Molecular Weight: 564.763

Synonyms:(S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionic acid

Chemical Property of (S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionic acid

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Technology Process of (S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionic acid

There total 1 articles about (S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2,2,6,6-tetraethyl-1-[1-(4-iodomethylphenyl)ethoxy]-4-methoxypiperidine (1003593-04-1) + (S)-N-(tert-butoxycarbonyl)serine (3262-72-4) → (S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionic acid (1003593-08-5)

Guidance literature:

(S)-N-(tert-butoxycarbonyl)serine; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

2,2,6,6-tetraethyl-1-[1-(4-iodomethylphenyl)ethoxy]-4-methoxypiperidine; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Further stages.;

DOI:10.1039/b713083j

Reference yield: 85.0%

(S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionic acid (1003593-08-5) + H-Ala-Ala-Phe-p-nirtoanilide (61043-41-2) → ((S)-1-((S)-1-{(S)-1-[(S)-1-(4-nitrophenylcarbamoyl)-2-phenylethylcarbamoyl]ethylcarbamoyl}ethylcarbamoyl)-2-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}ethyl)carbamic acid tert-butyl ester (1003593-27-8)

Guidance literature:

With 1-h; 4-m; 1-; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1039/b713083j

Reference yield: 78.0%

(S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionic acid (1003593-08-5) + H2N-Phe-Phe-Gly-OMe (105224-80-4) → {(S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionylamino)-3-phenylpropionylamino]-3-phenylpropionylamino}acetic acid methyl ester (1003593-22-3)

Guidance literature:

With 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1039/b713083j

upstream raw materials:

2,2,6,6-tetraethyl-1-[1-(4-iodomethylphenyl)ethoxy]-4-methoxypiperidine

(S)-N-(tert-butoxycarbonyl)serine

Downstream raw materials:

((S)-1-[(S)-1-(4-nitrophenylcarbamoyl)-2-phenylethylcarbamoyl]-2-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}ethyl)carbamic acid tert-butyl ester

((S)-1-((S)-1-{(S)-1-[(S)-1-(4-nitrophenylcarbamoyl)-2-phenylethylcarbamoyl]ethylcarbamoyl}ethylcarbamoyl)-2-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}ethyl)carbamic acid tert-butyl ester

{(S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{4-[1-(2,2,6,6-tetraethyl-4-methoxypiperidin-1-yloxy)ethyl]benzyloxy}propionylamino)-3-phenylpropionylamino]-3-phenylpropionylamino}acetic acid methyl ester

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