9-[(1R,2R,3S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobutyl]-9H-purin-6-ylamine

Base Information

Chemical Name:9-[(1R,2R,3S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobutyl]-9H-purin-6-ylamine
CAS No.:145351-79-7
Molecular Formula:C₃₃H₄₇N₅O₂Si₂
Molecular Weight:601.939
Hs Code.:

Synonyms:9-[(1R,2R,3S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobutyl]-9H-purin-6-ylamine

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Chemical Property of 9-[(1R,2R,3S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobutyl]-9H-purin-6-ylamine

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Technology Process of 9-[(1R,2R,3S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobutyl]-9H-purin-6-ylamine

There total 4 articles about 9-[(1R,2R,3S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobutyl]-9H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 145351-78-6
Methanesulfonic acid (1S,2S,3S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobutyl ester

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 145351-79-7
9-[(1R,2R,3S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobutyl]-9H-purin-6-ylamine

Guidance literature:: With 18-crown-6 ether; sodium hydride; In N,N-dimethyl-formamide; at 140 ℃; for 16h;

Reference yield:

: 145351-77-5
(1S,2S,3S)1-Methylsulfonyloxy-2-hydroxymethyl-3-tert-butyldiphenylsilyloxymethylcyclobutane

: 145351-79-7
9-[(1R,2R,3S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobutyl]-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 41 percent / NaH, 18-crown-6 / dimethylformamide / 16 h / 140 °C

With 18-crown-6 ether; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 145351-74-2
(1S,2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutanol

: 145351-79-7
9-[(1R,2R,3S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobutyl]-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 1) O₃, 2) NaBH₄ / 1) CH₂Cl₂, MeOH, -78 deg C, 2 h, 2) -78 deg C, 30 min

3: 95 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 41 percent / NaH, 18-crown-6 / dimethylformamide / 16 h / 140 °C

With sodium tetrahydroborate; 18-crown-6 ether; sodium hydride; ozone; triethylamine; In dichloromethane; N,N-dimethyl-formamide;