(1S,2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutanol

Base Information

Chemical Name:(1S,2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutanol
CAS No.:145351-74-2
Molecular Formula:C₃₅H₃₈O₂Si
Molecular Weight:518.771
Hs Code.:

Synonyms:(1S,2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutanol

Chemical Property:

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Technology Process of (1S,2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutanol

There total 1 articles about (1S,2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 145351-72-0
(1S,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxymethyl-cyclobutanol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 145351-74-2
(1S,2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutanol

: 145351-75-3
C₅₁H₅₆O₂Si₂

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 4h;

Reference yield: 90.0%

: 124-63-0
methanesulfonyl chloride

: 145351-74-2
(1S,2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutanol

: 145351-76-4
Methanesulfonic acid (1S,2R,3S)-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutyl ester

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;

Reference yield:

: 145351-74-2
(1S,2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(2,2-diphenyl-vinyl)-cyclobutanol

: 145351-77-5
(1S,2S,3S)1-Methylsulfonyloxy-2-hydroxymethyl-3-tert-butyldiphenylsilyloxymethylcyclobutane

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 1) O₃, 2) NaBH₄ / 1) CH₂Cl₂, MeOH, -78 deg C, 2 h, 2) -78 deg C, 30 min

With sodium tetrahydroborate; ozone; triethylamine; In dichloromethane;