1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride

Base Information

Chemical Name:1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride
CAS No.:942426-83-7
Molecular Formula:C₂₂H₂₄ClN₃O₃*ClH
Molecular Weight:450.365
Hs Code.:

Synonyms:1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride

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Chemical Property of 1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride

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Technology Process of 1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride

There total 1 articles about 1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 942468-07-7
methyl 1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylate

: 942426-83-7
1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride

Guidance literature:: methyl 1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylate; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 20 ℃; for 16h;

With hydrogenchloride; water; at 0 ℃; for 1h; pH=2;

Reference yield: 99.0%

: 942426-83-7
1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride

: 74-89-5
methylamine

: 942426-88-2
1-{3-[4-(3-Chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid methylamide

Guidance literature:: 1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 3h;

methylamine; In tetrahydrofuran; water; at 20 ℃; for 3h;

Reference yield: 70.0%

: 942426-83-7
1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride

: 942426-93-9
1-{3-[4-(3-Chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid amide

Guidance literature:: 1-{3-[4-(3-chloro-indazol-2-yl)-phenoxy]-propyl}-piperidine-4-carboxylic acid hydrochloride; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 3h;

With ammonia; In tetrahydrofuran; water; at 20 ℃; for 3h;