Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2-chloro-phenyl) ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2-chloro-phenyl) ester
• CAS No.: 86670-59-9
• Molecular Formula: C₂₉H₃₇Cl₂N₂O₈PSi
• Molecular Weight: 671.587
• Mol file: 86670-59-9.mol

Synonyms:Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2-chloro-phenyl) ester

Chemical Property of Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2-chloro-phenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2-chloro-phenyl) ester

There total 1 articles about Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2-chloro-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

bis(2-chlorophenyl) chlorophosphate (17776-78-2) + 5'-O-(tert-butyldimethylsilyl)-N(3)-methylthymidine (86670-58-8) → Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester bis-(2-chloro-phenyl) ester (86670-59-9)

Guidance literature:

With mesityllithium; In tetrahydrofuran; hexane; 1) -78 deg C, 1.5 h., 2) -78 deg C, 1 h;

DOI:10.1016/S0040-4039(00)86393-5

upstream raw materials:

bis(2-chlorophenyl) chlorophosphate

5'-O-(tert-butyldimethylsilyl)-N⁽³⁾-methylthymidine