2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-butyric acid methyl ester

Base Information

Chemical Name:2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-butyric acid methyl ester
CAS No.:77407-06-8
Molecular Formula:C₁₄H₂₂O₆
Molecular Weight:286.325
Hs Code.:

Synonyms:2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-butyric acid methyl ester

Suppliers and Price of 2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-butyric acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-butyric acid methyl ester

There total 7 articles about 2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 77406-92-9
2-methylene-3-(methoxymethyloxy) cyclohexanone

: 105-45-3
acetoacetic acid methyl ester

: 77407-06-8
2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-butyric acid methyl ester

Guidance literature:: With sodium hydride; In benzene; Ambient temperature;
DOI:10.1016/0040-4039(81)80164-5

Reference yield:

: 77406-95-2
6-Iodo-3-methoxymethoxy-2-methylene-hexanal

: 77407-06-8
2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: ZnI₂ / 1 h / warmed from 0 deg C to room temperature

2: 3N HCl / tetrahydrofuran / 0.25 h / 0 °C

3: p-TsOH / benzene

4: 79 percent / sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 40 °C

5: 1.) 3N HCl, 2.) 0.5percent NaOH / 1.) THF, 0deg C, 1 h, 2.) ether, 0 deg C, 1 min

6: 73 percent / NaH / benzene / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium hexamethyldisilazane; sodium hydride; toluene-4-sulfonic acid; zinc(II) iodide; In tetrahydrofuran; benzene;
DOI:10.1016/0040-4039(81)80164-5

Reference yield:

: 77406-94-1
2-Diethoxymethyl-6-iodo-hex-1-en-3-ol

: 77407-06-8
2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 2.) copper sulfate / 1.) diethylaniline, room temperature, 12 h, 2.) methanol-water, room temperature, 1 h

2: ZnI₂ / 1 h / warmed from 0 deg C to room temperature

3: 3N HCl / tetrahydrofuran / 0.25 h / 0 °C

4: p-TsOH / benzene

5: 79 percent / sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 40 °C

6: 1.) 3N HCl, 2.) 0.5percent NaOH / 1.) THF, 0deg C, 1 h, 2.) ether, 0 deg C, 1 min

7: 73 percent / NaH / benzene / Ambient temperature

With hydrogenchloride; sodium hydroxide; copper(I) sulfate; sodium hexamethyldisilazane; sodium hydride; toluene-4-sulfonic acid; zinc(II) iodide; In tetrahydrofuran; benzene;
DOI:10.1016/0040-4039(81)80164-5