N⁶-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

Base Information

• Chemical Name: N⁶-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat
• CAS No.: 75074-01-0
• Molecular Formula: C₅₂H₅₄ClN₆O₉PSi
• Molecular Weight: 1001.55

Synonyms:N⁶-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

Chemical Property of N⁶-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

Chemical Property:

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Technology Process of N⁶-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

There total 5 articles about N⁶-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-Benzoyl-5'-O-(monomethoxytrityl)adenosine (69504-00-3) → N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat (75074-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 42 percent / imidazole / pyridine

2: pyridine

With 1H-imidazole; In pyridine;

DOI:10.1016/S0040-4039(00)93649-9

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat (75074-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 42 percent / imidazole / pyridine

2: pyridine

With 1H-imidazole; In pyridine;

DOI:10.1016/S0040-4039(00)93649-9

Reference yield:

N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine (69504-10-5) → N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat (75074-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

In pyridine;

DOI:10.1016/S0040-4039(00)93649-9

upstream raw materials:

Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

3-Hydroxypropionitrile

N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine

2-chlorophenyl dichlorophosphate

Downstream raw materials:

N⁶-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

Triethylammonium-6-benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)phosphat>

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