5,5-bis(benzenesulfonyl)-1-[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]pentyl acetate

Base Information

Chemical Name:5,5-bis(benzenesulfonyl)-1-[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]pentyl acetate
CAS No.:1432519-09-9
Molecular Formula:C₃₃H₄₂O₉S₂
Molecular Weight:646.823
Hs Code.:

Synonyms:5,5-bis(benzenesulfonyl)-1-[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]pentyl acetate

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Chemical Property of 5,5-bis(benzenesulfonyl)-1-[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]pentyl acetate

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Technology Process of 5,5-bis(benzenesulfonyl)-1-[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]pentyl acetate

There total 5 articles about 5,5-bis(benzenesulfonyl)-1-[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]pentyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1432519-08-8
(5R)-3-[5,5-bis(benzenesulfonyl)-1-hydroxypentyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one

: 75-36-5
acetyl chloride

: 1432519-09-9
5,5-bis(benzenesulfonyl)-1-[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]pentyl acetate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃; for 3h; Cooling with ice;
DOI:10.1039/c3ob40115d

Reference yield: 83.0%

: 1432519-10-2
5,5-bis(benzenesulfonyl)-1-[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-3-(phenylselanyl)oxolan-3-yl]pentyl acetate

: 1432519-09-9
5,5-bis(benzenesulfonyl)-1-[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]pentyl acetate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 12h; Cooling with ice;
DOI:10.1039/c3ob40115d

Reference yield:

: 906520-19-2
5,5-bis(phenylthio)pentanal

: 1432519-09-9
5,5-bis(benzenesulfonyl)-1-[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]pentyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.75 h / -78 °C

1.2: 0.08 h

1.3: -78 °C

2.1: dmap; triethylamine / dichloromethane / 3 h / 0 °C / Cooling with ice

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 °C / Cooling with ice

With dmap; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/c3ob40115d