2-benzyl-N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2-methylpropanamide

Base Information

Chemical Name:2-benzyl-N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2-methylpropanamide
CAS No.:1623774-93-5
Molecular Formula:C₂₉H₃₁FN₄O
Molecular Weight:470.59
Hs Code.:

Synonyms:2-benzyl-N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2-methylpropanamide

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Chemical Property of 2-benzyl-N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2-methylpropanamide

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Technology Process of 2-benzyl-N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2-methylpropanamide

There total 5 articles about 2-benzyl-N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1623774-87-7
N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide

: 100-58-3
phenylmagnesium bromide

: 1623774-93-5
2-benzyl-N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2-methylpropanamide

Guidance literature:: N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide; phenylmagnesium bromide; With N,N,N,N,-tetramethylethylenediamine; zinc dibromide; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere; Schlenk technique;

With iron(III)-acetylacetonate; o-phenylenebis(diphenylphosphine); In toluene; at 20 ℃; for 0.166667h;

With 1,2-dichloro-2-methylpropane; In tetrahydrofuran; toluene; at 80 ℃; for 16h;
DOI:10.1002/anie.201311024

Reference yield:

: 622-79-7
benzyl azide

: 1623774-93-5
2-benzyl-N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: N,N,N,N,-tetramethylethylenediamine; zinc dibromide / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere; Schlenk technique

3.2: 0.17 h / 20 °C

3.3: 16 h / 80 °C

With copper(ll) sulfate pentahydrate; N,N,N,N,-tetramethylethylenediamine; sodium L-ascorbate; triethylamine; zinc dibromide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201311024

Reference yield:

: 2978-58-7
1,1-dimethylprop-3-ynylamine

: 1623774-93-5
2-benzyl-N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: N,N,N,N,-tetramethylethylenediamine; zinc dibromide / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere; Schlenk technique

3.2: 0.17 h / 20 °C

3.3: 16 h / 80 °C

With copper(ll) sulfate pentahydrate; N,N,N,N,-tetramethylethylenediamine; sodium L-ascorbate; triethylamine; zinc dibromide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201311024