N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide

Base Information

Chemical Name:N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide
CAS No.:1623774-87-7
Molecular Formula:C₂₃H₂₇FN₄O
Molecular Weight:394.492
Hs Code.:

Synonyms:N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide

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Chemical Property of N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide

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Technology Process of N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide

There total 4 articles about N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: C₁₁H₁₂ClFO

: 1310826-33-5
2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine

: 1623774-87-7
N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.201311024

Reference yield:

: 622-79-7
benzyl azide

: 1623774-87-7
N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Schlenk technique

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201311024

Reference yield:

: 2978-58-7
1,1-dimethylprop-3-ynylamine

: 1623774-87-7
N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-(4-fluorophenyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Schlenk technique

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201311024