(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

Base Information

• Chemical Name: (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone
• CAS No.: 134333-52-1
• Molecular Formula: C₂₃H₂₆N₂O₈
• Molecular Weight: 458.468
• Mol file: 134333-52-1.mol

Synonyms:(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

Chemical Property of (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

There total 1 articles about (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone (115820-52-5) + trimethoxonium tetrafluoroborate (420-37-1) → (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone (134333-52-1)

Guidance literature:

With Proton Sponge; In dichloromethane; at 25 ℃; for 120h;

DOI:10.1021/jo00030a006

Reference yield: 95.0%

(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone (134333-52-1) → (2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid (138694-13-0)

Guidance literature:

With lithium hydrogen peroxide; In tetrahydrofuran; water; at 0 ℃;

DOI:10.1021/jo00030a006

Reference yield:

(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone (134333-52-1) → (4R,3R)-4-(2,5-Dimethoxy-3-nitrophenyl)-4-methoxy-3-methylbutaoic acid (138694-15-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / 30percent aq. H₂O₂, sodium lithium hydroxide / tetrahydrofuran; H₂O / 0.5 h / 0 °C

2: (COCl)2, DMF / CH₂Cl₂ / 16 h / Ambient temperature

3: CH₂Cl₂; diethyl ether / 0.5 h / 0 °C

4: 87 percent / AgNO₃, H₂O / tetrahydrofuran / 23 h / 25 °C

With oxalyl dichloride; sodium lithium hydroxide; water; dihydrogen peroxide; silver nitrate; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane; water;

DOI:10.1021/jo00054a035

upstream raw materials:

(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

trimethoxonium tetrafluoroborate

Downstream raw materials:

(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid

(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride

(4R,3R)-4-(2,5-Dimethoxy-3-nitrophenyl)-4-methoxy-3-methylbutaoic acid

(4R,3R)-1-Diazo-4-(2,5-dimethoxy-3-nitrophenyl)-4-methoxy-3-methyl-2-butanone