(1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine

Base Information

Chemical Name:(1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine
CAS No.:1446141-84-9
Molecular Formula:C₂₁H₂₅NO₅S
Molecular Weight:403.499
Hs Code.:

Synonyms:(1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine

Chemical Property:

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Technology Process of (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine

There total 3 articles about (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1369963-66-5
(3S,3aR,4S,5R)-3-phenylsulfonyl-4,5-isopropylidenedioxy-hexahydropyrrolo[1,2-b]isoxazole

: 100-58-3
phenylmagnesium bromide

: 1446141-84-9
(1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;
DOI:10.1021/jo400873c

Reference yield: 50.0%

: 1369963-65-4
(3R,3aR,4S,5R)-3-phenylsulfonyl-4,5-isopropylidenedioxy-hexahydropyrrolo[1,2-b]isoxazole

: 100-58-3
phenylmagnesium bromide

: 1446141-84-9
(1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;
DOI:10.1021/jo400873c

Reference yield:

: 213598-45-9
3,4-isopropylidenedioxy-Δ¹-pyrroline-1-oxide

: 1446141-84-9
(1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 6 h / 20 °C

2: tetrahydrofuran; diethyl ether / 1 h / 0 °C

In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/jo400873c